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Review
. 2025 Aug 9:18:2767-2781.
doi: 10.2147/DMSO.S521095. eCollection 2025.

Advances in the Role of Stem Cell-Derived Exosomes in Diabetic Foot Wound Healing

Junbo Wang  1 , Yu-Jie Liang  2 , Xiaohua Pan  1
Affiliations
Review

Advances in the Role of Stem Cell-Derived Exosomes in Diabetic Foot Wound Healing

Junbo Wang et al. Diabetes Metab Syndr Obes. .

Abstract

Chronic hyperglycemia over a long period can lead to diabetes-related complications, of which diabetic foot ulcers continue to have a huge economic and social impact worldwide. Mesenchymal stem cell-derived exosomes (MSC-Exos) have demonstrated positive efficacy in the preclinical research and clinical trial phases of diabetic foot ulcer (DFU) treatment. In this review, we provide a brief overview of the properties of MSC-derived exosomes and their biological functions, summarize the therapeutic efficacy of Exos in the treatment of diabetic foot ulcers and its mechanism of action, and discuss innovative technologies including hydrogel scaffolds and 3D bioprinting to enhance the effectiveness of MSC - Exos in the treatment of diabetic foot ulcers. This paper also explores the application of innovative technologies such as hydrogel scaffolds and 3D bioprinting in enhancing the efficacy of MSC-Exos in the treatment of diabetic foot ulcers and highlights the key challenges faced in translating these advanced technologies from the laboratory to the clinic.

Keywords: chronic wounds; diabetic foot ulcers; stem cell-derived exosomes; tissue engineering; translational research.

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Conflict of interest statement

The authors report no conflict of interest in this work.

Figures

Figure 1
Figure 1
Biogenesis of exosomes.
See this image and copyright information in PMC

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