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. 2023 Feb:65:101116.
doi: 10.1016/j.jneuroling.2022.101116. Epub 2022 Nov 4.

Word Picture Verification Performance Reveals Auditory Comprehension Deficits in Primary Progressive Aphasia

Samuel Suh  1 , Elizabeth DeLuque  1 , Catherine Kelly  1 , Xander Lee  1 , Rachel Fabian Mace  1 , Kristina Ruch  1 , Massoud Sharif  1 , Melissa D Stockbridge  1 , Emilia Vitti  1 , Donna C Tippett  1   2   3
Affiliations

Word Picture Verification Performance Reveals Auditory Comprehension Deficits in Primary Progressive Aphasia

Samuel Suh et al. J Neurolinguistics. 2023 Feb.

Abstract

Word/picture verification has been found to be a sensitive measure of lexical-semantic abilities in post-stroke aphasia and reveals information about disruptions in semantic and phonological processing. Exploration of the nature of auditory comprehension deficits using word/picture verification has not been replicated in primary progressive aphasia (PPA). We tested 108 individuals with PPA [logopenic variant PPA (lvPPA), n = 50; nonfluent agrammatic PPA (nfaPPA), n = 36; semantic variant PPA (svPPA), n = 22] on a spoken word/picture verification task and a spoken word/picture matching task. The spoken word/picture matching task identified 22 (20%) of individuals as impaired, whereas the spoken word/picture verification task identified 51 (47%) of individuals as impaired (two-tailed p < 0.001). Errors on spoken word/picture verification were due to semantic rather than phonologic foils in lvPPA (nouns, p < 0.001; verbs, p < 0.001), svPPA (nouns, p < 0.001; verbs, p < 0.001), and for nouns (p = 0.001) but not verbs in nfaPPA. Spoken word/picture verification was a more sensitive measure of single-word auditory comprehension deficits in PPA than word/picture matching. The error pattern, consistent with the distributed model of semantic knowledge, suggests that degradation of semantic representations for both nouns and verbs can occur in lvPPA, which may help to distinguish lvPPA versus nfaPPA and guide treatment for anomia.

Keywords: auditory comprehension; phonologic; primary progressive aphasia; semantic.

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Conflict of interest statement

Samuel Suh: none Catherine Kelly: Receives salary support from NIH NIDCD R01 DC005375 and NIH NIDCD R01 DC015466. Xander Lee: Receives salary support from NIH NIDCD R01 DC005375 and NIH NIDCD R01 DC015466. Rachel Fabian Mace: Receives salary support from NIH NIDCD R01 DC005375 and NIH NIDCD R01 DC015466. Kristina Ruch: Receives salary support from NIH NIDCD R01 DC005375. Massoud Sharif: none Melissa L. Stockbridge: Receives salary support from NIH NIDCD R01 DC005375 and NIDCD P50 DC014664. Emilia Vitti: Receives salary support from NIH NIDCD R01 DC005375 and NIH NIDCD R01 DC015466. Donna C. Tippett: Receives salary support from NIH NIDCD/NIA R01 DC011317 and NIDCD P50 DC014664

Figures

Figure 1:
Figure 1:
Performance on Noun and Verb Spoken Word Picture Verification by Variant of Primary Progressive Aphasia lvPPA, logopenic primary progressive aphasia; nfaPPA, nonfluent agrammatic primary progressive aphasia; svPPA semantic variant primary progressive aphasia
See this image and copyright information in PMC

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