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. 2025 Aug 8;36(3):102652.
doi: 10.1016/j.omtn.2025.102652. eCollection 2025 Sep 9.

Gold nanoparticle-based delivery of Cas13d for targeted RNA virus defense

Natália Jordana Alves da Silva  1 , Marco Tullio Rodrigues Alves  1 , Flávia Alves França  1 , Pedro Pires Goulart Guimarães  1
Affiliations

Gold nanoparticle-based delivery of Cas13d for targeted RNA virus defense

Natália Jordana Alves da Silva et al. Mol Ther Nucleic Acids. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Schematic representation of the cellular uptake and antiviral activity of Au_NP-Cas13d These Au_NP-Cas13d enter cells via endocytosis or passive diffusion, enabling early antiviral action. For SARS-CoV-2, which replicates in endosomal vesicles, the antiviral effect was pronounced. In contrast, for ZIKV, which replicates in ER-Golgi compartments, the effect was reduced.
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