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. 2025 Jul 31:12:1649766.
doi: 10.3389/fsurg.2025.1649766. eCollection 2025.

Mortality risk prediction in octogenarians undergoing emergency colorectal surgery: a tertiary center experience and systematic review of the literature

Marco Brolese  1 , Arianna Vittori  1 , Matteo Todisco  2 , Nadine Zuin  1 , Vanessa Cusano  1 , Valeria Valli  1 , Lorenzo Vallese  1 , Nicola Baldan  1 , Michele Valmasoni  1 , Gianfranco Da Dalt  1 , Alberto Friziero  1
Affiliations

Mortality risk prediction in octogenarians undergoing emergency colorectal surgery: a tertiary center experience and systematic review of the literature

Marco Brolese et al. Front Surg. .

Abstract

Objective: Surgical colonic emergencies frequently occur in elderly patients. In these cases a comprehensive preoperative assessment is crucial to tailor surgical invasiveness to individual risk profiles and potentially improve clinical outcomes. The aim of our study was to identify predictors of in-hospital mortality in octogenarians undergoing emergency colorectal resections, and compare the short-term outcomes between elderly and younger patients.

Methods: This study included patients who underwent emergency colorectal resections at Our Department between January 2020 and December 2024. Exclusion criteria were age <18 years and palliative surgery. Patients were stratified into two cohorts: octogenarians (≥80 years, Group 1) and patients aged <80 years (Group 2). Baseline characteristics, perioperative variables, and short-term outcomes were compared and analyzed. A systematic review (PROSPERO: CRD420251050770) was conducted to identify the studies evaluating outcomes of emergency colorectal resections in octogenarians. MEDLINE (via PubMed), EMBASE, and EBSCOhost were searched from database inception to April 2025.

Results: Group 1 and Group 2 included 82 and 130 patients with median ages of 84 and 67 years, respectively. The in-hospital mortality rate was 24% in octogenarians and 8% in younger patients (p < 0.001). Multivariate logistic regression identified hyperlactatemia as an independent negative prognostic factor for in-hospital mortality in octogenarians (p = 0.01). Through a systematic review of the literature we identified 12 publications, and the mortality rate ranged between 7.0 and 37.8%.

Conclusions: Early identification of prognostic factors can improve clinical outcome in emergency scenarios. Our systematic review, the first reported in the literature, provides a comprehensive perspective in this field.

Keywords: acute care surgery; colectomy; emergencies; mortality; octogenarians; risk factors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram showing the study selection process of the systematic literature review.
See this image and copyright information in PMC

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