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Review
. 2025 Jul 31:16:1537769.
doi: 10.3389/fendo.2025.1537769. eCollection 2025.

Notch signaling in diabetic kidney disease: recent progress

Zhi-Hui Wang  1 , Wei Tu  2 , Ya-Ni Long  3 , Peng-Fei Li  4 , Kai-Ying He  1 , Jing Wu  1
Affiliations
Review

Notch signaling in diabetic kidney disease: recent progress

Zhi-Hui Wang et al. Front Endocrinol (Lausanne). .

Abstract

Diabetic kidney disease (DKD) is one of the most serious complications of diabetes mellitus (DM) and the main cause of end-stage renal disease (ESRD). The number of affected patients is increasing annually worldwide. Therefore, it is necessary to establish new strategies to treat DKD and improve prognosis. The Notch signaling pathway is involved in multiple mechanisms in DKD, including glomerular endothelial dysfunction, filtration barrier damage, podocyte EMT and dedifferentiation, tubulointerstitial fibrosis, proximal tubule cell dedifferentiation, macrophage polarization, etc. In addition, Notch signaling interacts with other pathways involved in DKD progression, such as TGF-β, Wnt/β-catenin, mTOR, AMPK, autophagy, etc. Therefore, new ideas for the future treatment of DKD may be provided through clarification of the role of the Notch signaling pathway and development of novel drugs.

Keywords: Notch signaling; diabetic kidney disease; podocyte; renal fibrosis; therapy.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Overview of the Notch signaling pathway and pivotal targets.
Figure 2
Figure 2
Role of Notch signaling in regulating DKD-associated endothelial cell dysfunction, podocyte dedifferentiation, and death.
Figure 3
Figure 3
Crosstalk between notch signaling and DKD-related signals and their role in regulating renal inflammation and fibrosis.
See this image and copyright information in PMC

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