Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jul 31:15:1604227.
doi: 10.3389/fonc.2025.1604227. eCollection 2025.

Regulation of sphingolipid metabolism in the immune microenvironment of gastric cancer: current insights and future directions

Yunqi Hua #  1 , Gangling Zhang #  1 , Yubo Liu  2 , Xiaoling Tian  2 , Xinyi Zhang  1 , Ge Song  2 , Qinggang Tian  1 , Fangrui Yin  3
Affiliations
Review

Regulation of sphingolipid metabolism in the immune microenvironment of gastric cancer: current insights and future directions

Yunqi Hua et al. Front Oncol. .

Abstract

In recent years, the role of sphingolipid metabolism in the tumor immune microenvironment has gradually gained attention, particularly in gastric cancer research. Sphingolipids are crucial components of cell membranes that regulate cell signaling and immune responses, making them important in tumor biology research. Despite numerous studies exploring the relationship between sphingolipid metabolism and gastric cancer, the specific regulatory mechanisms remain unclear. Further investigation is needed to understand their roles in the immune microenvironment. This article aims to review the regulatory mechanisms of sphingolipid metabolism in the immune microenvironment of gastric cancer, discussing its potential applications in tumor occurrence, development, and treatment. By analyzing current research progress, we will clarify the complex relationship between sphingolipid metabolism and immune cell interactions and look forward to future research directions, hoping to provide new ideas and strategies for immunotherapy in gastric cancer.

Keywords: gastric cancer; immune microenvironment; mechanistic research; regulatory role; sphingolipid metabolism.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Sphingolipid metabolic pathway diagram1.
Figure 2
Figure 2
Sphingolipid metabolic pathway diagram2.
Figure 3
Figure 3
S1P metabolic pathway.
Figure 4
Figure 4
The balance of Ceramide and S1P.
See this image and copyright information in PMC

References

    1. Giusti F, Martos C, Bettio M, Negrão Carvalho R, Zorzi M, Guzzinati S, et al. Geographical and temporal differences in gastric and oesophageal cancer registration by subsite and morphology in Europe. Front Oncol. (2024) 14:1250107. doi: 10.3389/fonc.2024.1250107, PMID: - DOI - PMC - PubMed
    1. Abele M, Grabner L, Blessing T, Block A, Agaimy A, Kratz C, et al. Epidemiology and characteristics of gastric carcinoma in childhood-an analysis of data from population-based and clinical cancer registries. Cancers (Basel). (2023) 15(1):317. doi: 10.3390/cancers15010317, PMID: - DOI - PMC - PubMed
    1. Anderson NM, Simon MC. The tumor microenvironment. Curr Biol. (2020) 30:R921–r925. doi: 10.1016/j.cub.2020.06.081, PMID: - DOI - PMC - PubMed
    1. Wang K, He H. Pancreatic tumor microenvironment. Adv Exp Med Biol. (2020) 1296:243–57. doi: 10.1007/978-3-030-59038-3_15, PMID: - DOI - PubMed
    1. Vishwakarma S, Arya N, Kumar A. Regulation of tumor immune microenvironment by sphingolipids and lysophosphatidic acid. Curr Drug Targets. (2022) 23:559–73. doi: 10.2174/1389450122666211208111833, PMID: - DOI - PubMed

LinkOut - more resources