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. 2025 Aug 16;14(4):tfaf125.
doi: 10.1093/toxres/tfaf125. eCollection 2025 Aug.

Response to "Comparative in vitro and in silico evaluation of the toxic effects of metformin and/or ascorbic acid, new treatment options in the treatment of Melasma"

Sharang Gupta  1
Affiliations

Response to "Comparative in vitro and in silico evaluation of the toxic effects of metformin and/or ascorbic acid, new treatment options in the treatment of Melasma"

Sharang Gupta. Toxicol Res (Camb). .
No abstract available

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Comment in

  • Response.
    Yalçın HT, Çakır DA, Yirün A, Sanajou S, Işık G, Bozdemir Ö, Özçelik İ, Bacanlı MG, Zeybek ND, Baydar T, Erkekoğlu P. Yalçın HT, et al. Toxicol Res (Camb). 2025 Sep 15;14(5):tfaf126. doi: 10.1093/toxres/tfaf126. eCollection 2025 Oct. Toxicol Res (Camb). 2025. PMID: 40980157 No abstract available.

References

    1. Yalçın HT et al. Comparative in vitro and in silico evaluation of the toxic effects of metformin and/or ascorbic acid, new treatment options in the treatment of melasma. Toxicol Res. 2025:14:tfaf025. 10.1093/toxres/tfaf025 - DOI - PMC - PubMed
    1. D'Mello SA, Finlay GJ, Baguley BC, Askarian-Amiri ME. Signaling pathways in melanogenesis. Int J Mol Sci. 2016:17:1141. 10.3390/ijms17071144 - DOI - PMC - PubMed
    1. Panich U, Onkoksoong T, Limsaengurai S, Akarasereenont P, Wongkajornsilp A. Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system. Arch Pharm Res. 2011:34:811–820. 10.1007/s12272-011-0515-3 - DOI - PubMed
    1. Lee SA, Son YO, Kook SH, Choi KC, Lee JC. Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase. Arch Dermatol Res. 2011:303:669–678. 10.1007/s00403-011-1158-4 - DOI - PubMed
    1. Garcia-Peterson LM et al. Sirtuins in skin and skin cancers. Skin Pharmacol Physiol. 2017:30:216–224. 10.1159/000477417 - DOI - PMC - PubMed

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