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Review
. 2025 Aug 19.
doi: 10.1007/s12012-025-10046-y. Online ahead of print.

Exploring the Impact of E-cigarettes on Cardiovascular Health: Insights from Preclinical and Clinical Studies

Tijana Simovic #  1 , Chloe L Matheson #  1 , Marisa Colon  1 , Caroline O Cobb  2 , Judith Voynow  3 , Youngdeok Kim  1 , Patrick Nana-Sinkam  4 , Ryan Garten  1 , Paula Rodriguez-Miguelez  5   6
Affiliations
Review

Exploring the Impact of E-cigarettes on Cardiovascular Health: Insights from Preclinical and Clinical Studies

Tijana Simovic et al. Cardiovasc Toxicol. .

Abstract

Electronic cigarettes are popular tobacco products that heat e-liquid into an aerosol for inhalation. Since their introduction to the market, electronic cigarettes have been considered a safer alternative to combustible tobacco products. However, most of today's users are adolescents and young adults naïve to tobacco products, who are drawn to e-cigarettes by appealing designs and targeted marketing, resulting in exposure to largely unknown short- and long-term health risks. While the cardiovascular effects of electronic cigarettes remain incompletely understood, there has been a growing concern surrounding their potential acute and chronic impact on cardiovascular health and disease risks. In this review, we examine the components of e-cigarettes and evaluate the cardiovascular effects of both acute and regular e-cigarette exposure, summarizing findings from existing preclinical and clinical studies to provide a comprehensive overview about the topic.

Keywords: Cardiotoxicity; Cardiovascular health; E-cigarettes; Tobacco products.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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