Sodium bicarbonate in critical illness: targeted or too broad? Author's reply

Ruth Miriam Blank¹, Sebastiaan Paul Blank², Kevin B Laupland^{3

4}, Kyle C White^{4

5

6

7}, Mahesh Ramanan^{8

9

10

11}

Affiliations

¹ Intensive Care Unit, Cairns Hospital, Cairns, Australia.
² Department of Anaesthesia, Cairns Hospital, Cairns, Australia.
³ Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Australia.
⁴ School of Medicine, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
⁵ Faculty of Medicine, Mayne Academy of Critical Care, University of Queensland, St Lucia, Australia.
⁶ Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, Australia.
⁷ Intensive Care Unit, Queen Elizabeth II Jubilee Hospital, Coopers Plains, Australia.
⁸ Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Australia. Mahesh.Ramanan@health.qld.gov.au.
⁹ School of Medicine, Faculty of Health, Queensland University of Technology, Brisbane, Australia. Mahesh.Ramanan@health.qld.gov.au.
¹⁰ Intensive Care Unit, Caboolture Hospital, Caboolture, Australia. Mahesh.Ramanan@health.qld.gov.au.
¹¹ Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, Australia. Mahesh.Ramanan@health.qld.gov.au.

PMID: 40828467
DOI: 10.1007/s00134-025-08091-w

Sodium bicarbonate in critical illness: targeted or too broad? Author's reply

Ruth Miriam Blank et al. Intensive Care Med. 2025.

. 2025 Aug 19.

doi: 10.1007/s00134-025-08091-w. Online ahead of print.

Authors

Ruth Miriam Blank¹, Sebastiaan Paul Blank², Kevin B Laupland^{3

4}, Kyle C White^{4

5

6

7}, Mahesh Ramanan^{8

9

10

11}

Affiliations

¹ Intensive Care Unit, Cairns Hospital, Cairns, Australia.
² Department of Anaesthesia, Cairns Hospital, Cairns, Australia.
³ Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Australia.
⁴ School of Medicine, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
⁵ Faculty of Medicine, Mayne Academy of Critical Care, University of Queensland, St Lucia, Australia.
⁶ Intensive Care Unit, Princess Alexandra Hospital, Woolloongabba, Australia.
⁷ Intensive Care Unit, Queen Elizabeth II Jubilee Hospital, Coopers Plains, Australia.
⁸ Intensive Care Services, Royal Brisbane and Women's Hospital, Herston, Australia. Mahesh.Ramanan@health.qld.gov.au.
⁹ School of Medicine, Faculty of Health, Queensland University of Technology, Brisbane, Australia. Mahesh.Ramanan@health.qld.gov.au.
¹⁰ Intensive Care Unit, Caboolture Hospital, Caboolture, Australia. Mahesh.Ramanan@health.qld.gov.au.
¹¹ Critical Care Division, The George Institute for Global Health, University of New South Wales, Sydney, Australia. Mahesh.Ramanan@health.qld.gov.au.

PMID: 40828467
DOI: 10.1007/s00134-025-08091-w

No abstract available

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Conflict of interest statement

Declarations. Conflicts of interest: All authors have no conflict of interest to declare. Ethical approval: This is an author’s reply to a letter. Ethics approval is not applicable.

References

1. Chen Q, Zheng Q (2025) Sodium bicarbonate in critical illness: targeted or too broad? Intensive Care Med. https://doi.org/10.1007/s00134-025-08085-8 - DOI - PubMed - PMC
1. Blank SP, Blank RM, Laupland KB et al (2025) Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation. Intensive Care Med 51:1078–1086. https://doi.org/10.1007/s00134-025-07979-x - DOI - PubMed - PMC
1. Igelström E, Craig P, Lewsey J et al (2022) Causal inference and effect estimation using observational data. J Epidemiol Community Health 76:960–966. https://doi.org/10.1136/jech-2022-219267 - DOI
1. Jaber S, Paugam C, Futier E et al (2018) Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet Lond Engl 392:31–40. https://doi.org/10.1016/S0140-6736(18)31080-8 - DOI
1. Jung B, Huguet H, Molinari N, Jaber S (2023) Sodium bicarbonate for the treatment of severe metabolic acidosis with moderate or severe acute kidney injury in the critically ill: protocol for a randomised clinical trial (BICARICU-2). BMJ Open 13:e073487. https://doi.org/10.1136/bmjopen-2023-073487 - DOI - PubMed - PMC

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Sodium bicarbonate in critical illness: targeted or too broad? Author's reply

Affiliations

Sodium bicarbonate in critical illness: targeted or too broad? Author's reply

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