Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Oct;51(10):1954-1955.
doi: 10.1007/s00134-025-08091-w. Epub 2025 Aug 19.

Sodium bicarbonate in critical illness: targeted or too broad? Author's reply

Ruth Miriam Blank  1 , Sebastiaan Paul Blank  2 , Kevin B Laupland  3   4 , Kyle C White  4   5   6   7 , Mahesh Ramanan  8   9   10   11
Affiliations

Sodium bicarbonate in critical illness: targeted or too broad? Author's reply

Ruth Miriam Blank et al. Intensive Care Med. 2025 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflicts of interest: All authors have no conflict of interest to declare. Ethical approval: This is an author’s reply to a letter. Ethics approval is not applicable.

References

    1. Chen Q, Zheng Q (2025) Sodium bicarbonate in critical illness: targeted or too broad? Intensive Care Med. https://doi.org/10.1007/s00134-025-08085-8 - DOI - PubMed - PMC
    1. Blank SP, Blank RM, Laupland KB et al (2025) Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation. Intensive Care Med 51:1078–1086. https://doi.org/10.1007/s00134-025-07979-x - DOI - PubMed - PMC
    1. Igelström E, Craig P, Lewsey J et al (2022) Causal inference and effect estimation using observational data. J Epidemiol Community Health 76:960–966. https://doi.org/10.1136/jech-2022-219267 - DOI
    1. Jaber S, Paugam C, Futier E et al (2018) Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet Lond Engl 392:31–40. https://doi.org/10.1016/S0140-6736(18)31080-8 - DOI
    1. Jung B, Huguet H, Molinari N, Jaber S (2023) Sodium bicarbonate for the treatment of severe metabolic acidosis with moderate or severe acute kidney injury in the critically ill: protocol for a randomised clinical trial (BICARICU-2). BMJ Open 13:e073487. https://doi.org/10.1136/bmjopen-2023-073487 - DOI - PubMed - PMC

LinkOut - more resources