Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 19;15(1):30311.
doi: 10.1038/s41598-024-80462-7.

Association of new Life's Essential 8 with biological aging among the national health and nutrition examination surveys

Xiaoli Chen  1 , Xin Yin  2 , Xin Chen  1 , Yajie Gao  3 , Nan Ye  3 , Xingkang He  4
Affiliations

Association of new Life's Essential 8 with biological aging among the national health and nutrition examination surveys

Xiaoli Chen et al. Sci Rep. .

Abstract

The Life's Essential 8 (LE8) score was updated by the American Heart Association, which constituted cardiovascular health (CVH) and was significantly associated with overall and cardiovascular disease-specific mortality. The aim of this research was to evaluate the connection between LE8, the newly revised indicator of cardiovascular health, and the acceleration of biological age. Participants for this study were selected from the National Health and Nutrition Examination Survey. The LE8 scores, derived from measurements following the American Heart Association definitions, were categorized into three levels: low, moderate, and high, on a scale of 0 to 100. The PhenoAge algorithm was used to compute biological age, while the PhenoAge advancement was used to assess biological age acceleration. Linear and logistic regression analyses were used to examine the association between the LE8 score and biological age. A total of 17,153 individuals with an average age of 47.54 were included in the study. The average LE8 score was 68, and the average Phenotypic age was 44.61. Individuals with higher LE8 scores were found to have a younger Phenotypic age, as demonstrated by their lower PhenoAge scores. After controlling for potential confounding variables, a higher LE8 score was found to be associated with a decrease in PhenoAge advancement (β = - 1.22, P < 0.01) and a lower likelihood of biological aging (OR = 0.65, P < 0.01). Both health behavior and health factor scores were associated with biological aging (both P < 0.01). Each type of LE8 score in the high group was positively associated with biological aging (both P < 0.01). A significant inverse association between LE8 score and biological aging was observed in all subgroups (both P < 0.01). The LE8 and its subscale scores showed a negative association with the likelihood of phenotypic aging. Maintaining ideal CVH levels could be advantageous in avoiding the potential acceleration of biological aging.

Keywords: Cardiovascular health; Life’s Essential 8; NHANES; Phenotypic age.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The National Center for Health Statistics Ethics Review Board approved the study protocol and all participants provided written informed consent.

Figures

Fig. 1
Fig. 1
Flowchart for study identification, screening, and selection. A flow diagram for participant selection in the study.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Fernandes, M. et al. Systematic analysis of the gerontome reveals links between aging and age-related diseases. Hum. Mol. Genet.25 (21), 4804–4818 (2016). - PMC - PubMed
    1. Lutz, W., Sanderson, W. & Scherbov, S. The coming acceleration of global population ageing. Nature451 (7179), 716–719 (2008). - PubMed
    1. Phillip, J. M., Aifuwa, I., Walston, J. & Wirtz, D. The mechanobiology of aging. Annu. Rev. Biomed. Eng.17, 113–141 (2015). - PMC - PubMed
    1. Guo, J. et al. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. Signal. Transduct. Target. Ther.7 (1), 391 (2022). - PMC - PubMed
    1. Xia, X., Chen, W., McDermott, J. & Han, J. J. Molecular and phenotypic biomarkers of aging. F1000Res6, 860 (2017). - PMC - PubMed

LinkOut - more resources