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. 2025 Aug;24(8):e70412.
doi: 10.1111/jocd.70412.

Periprocedural Use of Hypochlorous Acid Mist for Improving Healing and Cosmesis of the Face After Laser

Marianna Blyumin-Karasik  1 , Jessica Colon  2 , Sophie Gaer  1 , Isabella Vigil  1 , Sylvie Nguyen  2 , Jordan Rosen  1
Affiliations

Periprocedural Use of Hypochlorous Acid Mist for Improving Healing and Cosmesis of the Face After Laser

Marianna Blyumin-Karasik et al. J Cosmet Dermatol. 2025 Aug.

Abstract

Background: Laser resurfacing treatments have revolutionized dermatological procedures by improving skin texture, tone, and quality. Effective periprocedural care remains essential to reduce side effects, support healing, and optimize aesthetic outcomes. Hypochlorous acid (HOCl), a naturally occurring oxidant with anti-inflammatory and antimicrobial properties, has demonstrated efficacy in promoting wound healing and minimizing scarring.

Aim: To evaluate the use of stabilized HOCl mist in the periprocedural care of patients undergoing laser resurfacing.

Methods: Ten patients underwent treatment with UltraClear, CO2RE, and/or GentleMax Pro laser devices. Stabilized HOCl mist was applied before and after the procedure, with continued application twice daily for 1 week posttreatment. Follow-up assessments at 1-3 weeks and 1-3 months post-procedure included clinical photography, tolerability evaluation, and aesthetic outcome assessment. Outcomes measured included Clinician Erythema Assessment (CEA), 4-point Edema Scale, Investigator Global Assessment of Pigmentation Scale (IPA), and Global Aesthetic Improvement Scale (GAIS). Statistical analysis was performed using the Friedman and Wilcoxon signed-rank tests.

Results: HOCl mist was associated with accelerated recovery, including a noticeable reduction in erythema and pigmentation. Statistically significant improvements were observed in CEA (p = 0.007) and IPA (p = 0.012) scores, indicating reduced clinical severity and pigment alteration. Edema and GAIS scores showed no statistically significant change.

Conclusion: Stabilized HOCl mist is well-tolerated and may significantly aid post-procedural recovery by minimizing side effects and reducing discomfort. Results support the potential role of stabilized HOCl mist as a beneficial adjunct in post-laser skincare, contributing to faster healing, reduced inflammation, and enhanced cosmetic results.

Keywords: aesthetic; cosmeceuticals; hypochlorous acid; integrated skincare; laser treatment; photoaging; resurfacing laser.

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Conflict of interest statement

Marianna Blyumin‐Karasik, MD is a founder and CEO of Stamina Beauty LLC, manufacturer of HOCl mist.

Figures

FIGURE 1
FIGURE 1
Clinical photographs before and after laser treatment.
See this image and copyright information in PMC

References

    1. Haykal D., Cartier H., Goldberg D., and Gold M., “Advancements in Laser Technologies for Skin Rejuvenation: A Comprehensive Review of Efficacy and Safety,” Journal of Cosmetic Dermatology 23, no. 10 (2024): 3078–3089, 10.1111/jocd.16514. - DOI - PubMed
    1. UltraClear Laser Skin Rejuvenation Solutions , “UltraClear” (2024), https://ultraclearlaser.com/.
    1. Candela , (2020), https://marketing.candelamedical.com/EMEA‐HQ‐CP‐2020‐12‐CO2RE‐LookBook_R....
    1. Blyumin‐Karasik M., Colon J., Nguyen S., and Rosen J., “Laser and Skin‐Care Synergy: A Post‐Laser Application of Novel Adaptogenic Moisturizing Serum for Improving Healing and Cosmesis on the Face,” Journal of Cosmetic Dermatology 24, no. 2 (2025): e16668, 10.1111/jocd.16668. - DOI - PMC - PubMed
    1. Li D., Lin S. B., and Cheng B., “Complications and Posttreatment Care Following Invasive Laser Skin Resurfacing: A Review,” Journal of Cosmetic and Laser Therapy 20, no. 3 (2018): 168–178, 10.1080/14764172.2017.1400166. - DOI - PubMed

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