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. 2025 Aug 20:jjaf148.
doi: 10.1093/ecco-jcc/jjaf148. Online ahead of print.

Micronutrients are associated with endoscopic postoperative recurrence in Crohn's disease: a multicenter prospective cohort study in North america

Michiel T J Bak  1   2   3 , Karen Boland  1   2   4 , Shadi Nayeri  1   2 , Krzysztof Borowksi  1   2 , Pablo A Olivera  1   2 , Cristian Hernandez-Rocha  1   2   5 , Williams Turpin  1   2 , Joanne M Stempak  1   2 , Steven R Brant  6   7 , Judy H Cho  8 , Richard H Duerr  9 , Talin Haritunians  10 , Mark G Lazarev  7 , Emebet Mengesha  10 , Dermot P B McGovern  10 , John D Rioux  11 , L Philip Schumm  12 , Sun-Ho Lee  1   2 , Mark S Silverberg  1   2 ; NIDDK Inflammatory Bowel Disease Genetics Consortium
Collaborators, Affiliations

Micronutrients are associated with endoscopic postoperative recurrence in Crohn's disease: a multicenter prospective cohort study in North america

Michiel T J Bak et al. J Crohns Colitis. .

Abstract

Background and aims: Diet may influence the disease course in inflammatory bowel disease, but its role in postoperative outcomes for Crohn's disease (CD) remains unclear. This study aimed to assess the association of macro- and micronutrient intake with endoscopic postoperative recurrence (ePOR) in a prospective multicenter cohort.

Methods: Patients with CD following ileocolic resection were prospectively recruited from six North American centers. Primary study outcome was ePOR (modified Rutgeerts' score ≥i2a) during follow-up. Nutritional intake was assessed through two-day food diaries verified by dietitian-delivered interview. Associations between nutrient intake and ePOR were evaluated. Random forest models with 10-fold cross-validation assessed the predictive value of nutrients and clinical factors for ePOR.

Results: A total of 520 food diaries from 103 patients were analyzed; 37 patients (36%) experienced ePOR. Univariate analysis identified eight nutrients associated with ePOR including lower intake of isoflavones (genistein, daidzein, glycitein; p < 0.01), inositol (p < 0.01), pinitol (p = 0.02), provitamin-A carotenoid (p < 0.01), xylitol (p = 0.03) and parinaric Acid (p = 0.03). Sensitivity analysis confirmed the association of lower intake of all isoflavones (p < 0.01) and pinitol (p = 0.04) with ePOR at first postoperative colonoscopy. Random forest models showed poor discrimination for clinical factors alone (AUC 0.59) but an acceptable discrimination for nutrients alone (AUC 0.67), which improved when combining nutrients and clinical factors (AUC 0.71).

Conclusion: Lower intake of specific micronutrients is associated with ePOR in CD patients. A machine-learning model combining nutrient intake and clinical factors enhanced the prediction of ePOR. These findings highlight the importance of postoperative nutritional assessment and suggest dietary interventions may help prevent postoperative recurrence in CD.

Keywords: Crohn’s disease; diet; nutrients; postoperative recurrence.

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