Published Erratum
doi: 10.1073/pnas.2519923122.
Epub 2025 Aug 20.
Correction for Kuroda et al., Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
- PMID: 40833421
- PMCID: PMC12403125
- DOI: 10.1073/pnas.2519923122
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Published Erratum
Correction for Kuroda et al., Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
Treatment with imatinib induces increased Bim expression and Bim dephosphorylation in Ph1+ human leukemic cells. K562 cells (A) or BV173 cells (B) were treated for the indicated amount of time with the indicated doses of imatinib. Western blotting was performed with an anti-Bim antibody and as a loading control with antibodies to HSP70 or β-actin. (C) K562 cells were treated for 3 or 6 h with 1 μM imatinib. Semiquantitative RT-PCR was performed to determine levels of bim mRNA (cycles: 25, 30, and 35). Semiquantitative RT-PCR for β-actin mRNA was used as a control (cycles: 20, 25, and 30). (D) K562 cells were left untreated or were treated for 24 h with 1.5 μM imatinib. Bim proteins were purified on an anti-Bim antibody affinity column and then analyzed by 2D gel electrophoresis. Arrows indicate the position of highly phosphorylated Bim from untreated cells.
Erratum for
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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14907-12. doi: 10.1073/pnas.0606176103. Epub 2006 Sep 22. Proc Natl Acad Sci U S A. 2006. PMID: 16997913 Free PMC article.
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