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. 2025 Aug 20.
doi: 10.1007/s11030-025-11286-4. Online ahead of print.

Iron‑catalyzed divergent synthesis of carbazole-based di-/triarylmethanes

Yi-Jun Jiang  1 , Hao-Lan Hu #  1 , Yu-Dan Niu  1 , Meng-Yuan Li  1 , Peng Chen #  2
Affiliations

Iron‑catalyzed divergent synthesis of carbazole-based di-/triarylmethanes

Yi-Jun Jiang et al. Mol Divers. .

Abstract

A simple and efficient iron-catalyzed divergent dehydrative coupling of carbazoles and benzylic alcohols has been developed. By using different iron catalysts, mono-substituted or di-substituted carbazole-based di-/triarylmethanes, some of which are bioactive and potential pharmaceutical molecules or potential molecular precursors for optoelectronic materials, were synthesized site-selectively from the same set of reactants. This method was demonstrated with 68 examples, in up to 98% yield and with broad functional group compatibilities.

Keywords: Benzylic alcohols; Carbazole; Diarylmethanes; Divergent synthesis; Iron catalysts; Triarylmethanes.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

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References

    1. Zhang T, Dong X, Jalani HB, Zou J, Li G, Lu H (2019) Iridium-catalyzed C–H amination/cyclization for medium to large n-heterocycle-fused dihydroquinazolinones. Org Lett 21:3706–3710. https://doi.org/10.1021/acs.orglett.9b01167 - DOI - PubMed
    1. Xi C-C, Zhao X-J, Tian J-M, Chen Z-M, Zhang K, Zhang F-M, Tu Y-Q, Dong J-W (2020) Atroposelective synthesis of axially chiral 3-arylindoles by copper-catalyzed asymmetric cross-coupling of indoles with quinones and naphthoquinones. Org Lett 22:4995–5000. https://doi.org/10.1021/acs.orglett.0c01558 - DOI - PubMed
    1. Liu B, Liu M, Li Q, Li Y, Feng K, Zhou Y (2020) The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source. Org Biomol Chem 18:6108–6114. https://doi.org/10.1039/d0ob00485e - DOI - PubMed
    1. Xu X-K, Liu J-W, Li D-Y, Liu P-N (2021) Pd-catalyzed direct C–H activation for the C5-olefination of methyleneindolinones. J Org Chem 86:7288–7295. https://doi.org/10.1021/acs.joc.1c00637 - DOI - PubMed
    1. Wang Y, Zhou X, Shan W, Liao R, Deng Y, Peng F, Shao Z (2022) Construction of axially chiral indoles by cycloaddition-isomerization via atroposelective phosphoric acid and silver sequential catalysis. ACS Catal 12:8094–8103. https://doi.org/10.1021/acscatal.2c02574 - DOI

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