Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 20.
doi: 10.1007/s11030-025-11286-4. Online ahead of print.

Iron‑catalyzed divergent synthesis of carbazole-based di-/triarylmethanes

Yi-Jun Jiang  1 , Hao-Lan Hu #  1 , Yu-Dan Niu  1 , Meng-Yuan Li  1 , Peng Chen #  2
Affiliations

Iron‑catalyzed divergent synthesis of carbazole-based di-/triarylmethanes

Yi-Jun Jiang et al. Mol Divers. .

Abstract

A simple and efficient iron-catalyzed divergent dehydrative coupling of carbazoles and benzylic alcohols has been developed. By using different iron catalysts, mono-substituted or di-substituted carbazole-based di-/triarylmethanes, some of which are bioactive and potential pharmaceutical molecules or potential molecular precursors for optoelectronic materials, were synthesized site-selectively from the same set of reactants. This method was demonstrated with 68 examples, in up to 98% yield and with broad functional group compatibilities.

Keywords: Benzylic alcohols; Carbazole; Diarylmethanes; Divergent synthesis; Iron catalysts; Triarylmethanes.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

References

    1. Zhang T, Dong X, Jalani HB, Zou J, Li G, Lu H (2019) Iridium-catalyzed C–H amination/cyclization for medium to large n-heterocycle-fused dihydroquinazolinones. Org Lett 21:3706–3710. https://doi.org/10.1021/acs.orglett.9b01167 - DOI - PubMed
    1. Xi C-C, Zhao X-J, Tian J-M, Chen Z-M, Zhang K, Zhang F-M, Tu Y-Q, Dong J-W (2020) Atroposelective synthesis of axially chiral 3-arylindoles by copper-catalyzed asymmetric cross-coupling of indoles with quinones and naphthoquinones. Org Lett 22:4995–5000. https://doi.org/10.1021/acs.orglett.0c01558 - DOI - PubMed
    1. Liu B, Liu M, Li Q, Li Y, Feng K, Zhou Y (2020) The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source. Org Biomol Chem 18:6108–6114. https://doi.org/10.1039/d0ob00485e - DOI - PubMed
    1. Xu X-K, Liu J-W, Li D-Y, Liu P-N (2021) Pd-catalyzed direct C–H activation for the C5-olefination of methyleneindolinones. J Org Chem 86:7288–7295. https://doi.org/10.1021/acs.joc.1c00637 - DOI - PubMed
    1. Wang Y, Zhou X, Shan W, Liao R, Deng Y, Peng F, Shao Z (2022) Construction of axially chiral indoles by cycloaddition-isomerization via atroposelective phosphoric acid and silver sequential catalysis. ACS Catal 12:8094–8103. https://doi.org/10.1021/acscatal.2c02574 - DOI

LinkOut - more resources