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. 2025 Aug 20.
doi: 10.1007/s11547-025-02074-z. Online ahead of print.

Simultaneous generation of color-coded arteriography, venography, and dynamic angiography: methodology and clinical applications in stroke

Heekyung Kim  1 , Hong Gee Roh  2   3 , Jin Tae Kwak  3   4 , Hee Jong Ki  3   5 , In Seong Kim  3   6 , Sumin Jung  3   4 , Hyun Yang  3   4 , Jeong Jin Park  7 , Yoo Sung Jeon  8 , Hyun Jeong Kim  9   10
Affiliations

Simultaneous generation of color-coded arteriography, venography, and dynamic angiography: methodology and clinical applications in stroke

Heekyung Kim et al. Radiol Med. .

Abstract

Cerebrovascular accident is a leading cause of death and disability. Early detection of cerebrovascular diseases is crucial for timely treatment. This study introduces a novel method for the simultaneous generation of color-coded arteriography, venography, and dynamic angiography derived from dynamic contrast-enhanced magnetic resonance angiography and computed tomography perfusion. By realigning source images into time series volume data, this approach enables the classification of five dynamic phases, allowing for the creation of detailed angiographic images and facilitating a comprehensive evaluation of cerebrovascular accidents in the emergency room. The method enables rapid assessment of ischemic strokes, improving patient selection for recanalization therapy, and aids in the early diagnosis of other cerebrovascular diseases, including cerebral venous thrombosis and arteriovenous shunts. We demonstrate the clinical applications of this technique, highlighting its potential to enhance the accuracy and speed of cerebrovascular imaging, making it a valuable first-line diagnostic tool for stroke patients.

Keywords: Angiography; Cerebrovascular disorders; Computed tomography angiography; Magnetic resonance angiography; Stroke; Venography.

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Conflict of interest statement

Declarations. Competing interests: Heekyung Kim, Jeong Jin Park, and Yoo Sung Jeon have no financial interests. Hong Gee Roh, Jin Tae Kwak, In Seong Kim, and Hyun Jeong Kim are founders of DeepClue Inc. Hee Jong Ki is a director at DeepClue Inc. Sumin Jung and Hyun Yang are employees at DeepClue Inc. Ethical approval: All methods were carried out in accordance with relevant guidelines and regulations of the Declaration of Helsinki and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines for reporting observational study. This is a retrospective study based on a prospectively collected database involving human participants and their data, approved by the local institutional review boards of Konkuk University Medical Center (KUMC0114-01–100-007) and Daejeon St. Mary’s Hospital (DC16OIMI0043). Consent to participate: Written informed consent was obtained from all patients. Consent to publish: The authors affirm that human research participants provided informed consent for publication of the images in Figs. 2–4.

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