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. 2025 Aug 18;51(4):e20250066.
doi: 10.36416/1806-3756/e20250066. eCollection 2025.

Influence of ADRB2 variants on bronchodilator response and asthma control in a mixed population

Pedro Augusto Silva Dos Santos Rodrigues  1 , Álvaro Augusto Souza da Cruz Filho  2 , Helena Mariana Pitangueira Teixeira  1 , Luciano Gama da Silva Gomes  1 , Hatilla Dos Santos Silva  1 , Juliana Lopes Rodrigues  1 , Almirane Lima de Oliveira  1 , Cinthia Vila Nova Santana  2 , Gabriela Pimentel Pinheiro das Chagas  2 , Camila Alexandrina Viana de Figueiredo  1 , Ryan Dos Santos Costa  1
Affiliations

Influence of ADRB2 variants on bronchodilator response and asthma control in a mixed population

Pedro Augusto Silva Dos Santos Rodrigues et al. J Bras Pneumol. .

Abstract

Objective: Given that b2 agonists constitute the primary treatment for asthma and that treatment response varies as a result of polymorphisms in the ADRB2 gene, we sought to investigate the associations between ADRB2 gene variants and bronchodilator response (BDR) in asthma patients.

Methods: A genetic database comprising 813 individuals was analyzed for variants in the ADRB2 gene. A longitudinal analysis of severe asthma patients was performed to evaluate changes in BDR over time.

Results: The rs1042713, rs1042714, and rs1042717 variants were associated with age-related changes in BDR in patients with severe asthma. The G allele (rs1042714) and the A allele (rs1042717) were associated with uncontrolled asthma, with carriers of the G46/G79/A252 alleles showing a higher risk of difficult-to-control asthma. Notably, no association was found between these variants and ADRB2 expression levels.

Conclusions: Our findings suggest that a genetic panel including ADRB2 variants, as well as age-related differences in BDR, is a useful complementary tool in asthma management.

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Conflict of interest statement

CONFLICTS OF INTEREST: None declared.

Figures

Figure 1
Figure 1. Correlation between rs1042713 and variations in longitudinal bronchodilator response. In A, overlaid smooths with a shaded area stratified by the number of A alleles-0, 1, or 2-and bronchodilator response adjusted for covariates. In B, density graphs for individuals stratified by bronchodilator response, grouped by number of A alleles and age.
Figure 2
Figure 2. Correlation between rs1042714 and variations in longitudinal bronchodilator response. In A, overlaid smooths with a shaded area stratified by the number of G alleles-0, 1, or 2-and bronchodilator response adjusted for covariates. In B, density graphs for individuals stratified by bronchodilator response, grouped by number of A alleles and age.
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