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. 2025 Aug 18:S0016-5107(25)01917-0.
doi: 10.1016/j.gie.2025.08.015. Online ahead of print.

Three-dimensional volume estimates of pancreatic fluid collections in relation to clinical outcomes of EUS-guided treatment

Montinee Supchatura  1 , Tomotaka Saito  2 , Atsuhiro Masuda  3 , Arata Sakai  3 , Masahiro Tsujimae  3 , Mamoru Takenaka  4 , Shunsuke Omoto  4 , Tomohiro Yamazaki  4 , Tatsuya Sato  2 , Tsuyoshi Hamada  5 , Takuji Iwashita  6 , Shinya Uemura  6 , Ryota Nakano  7 , Hideyuki Shiomi  7 , Toshio Fujisawa  8 , Sho Takahashi  8 , Saburo Matsubara  9 , Kentaro Suda  9 , Akinori Maruta  10 , Kensaku Yoshida  10 , Keisuke Iwata  11 , Yuhei Iwasa  11 , Nobuhiko Hayashi  12 , Tsuyoshi Mukai  13 , Ichiro Yasuda  12 , Hiroyuki Isayama  8 , Yousuke Nakai  14 ; WONDERFUL Study Group in Japan
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Free article

Three-dimensional volume estimates of pancreatic fluid collections in relation to clinical outcomes of EUS-guided treatment

Montinee Supchatura et al. Gastrointest Endosc. .
Free article

Abstract

Background and aims: The 3-dimensional (3D) volume of a pancreatic fluid collection (PFC) has not been fully investigated in EUS-guided treatment.

Methods: In 372 patients, we examined the 3D volume in relation to the clinical outcomes.

Results: In walled-off necrosis, 3D volume was associated with time to clinical success and in-hospital mortality with a multivariable subdistribution hazard ratio of 0.43 (95% CI, 0.28-0.66; Ptrend = .010) and a multivariable odds ratio of 30.9 (95% CI, 4.31-222; Ptrend = .004), respectively (for ≥1000 cm3 vs < 250 cm3). In pseudocysts, 3D volume was associated with in-hospital mortality (Ptrend = .014) with a multivariable odds ratio of 12.5 (95% CI, 0.81-193; for ≥500 cm3 vs < 100 cm3). The maximum diameter represented a comparable model goodness-of-fit.

Conclusions: PFC volume was associated with the outcomes of EUS-guided interventions, and the maximum diameter may be a reasonable surrogate.

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Conflict of interest statement

Disclosure The following authors disclosed financial relationships: H. Isayama: Research funding from Boston Scientific Japan, Fujifilm, and Piolax Medical Devices; honoraria from Boston Scientific Japan, Century Medical, Create Medic, Fujifilm, Gadelius Medical, Hitachi Medical, Japan Lifeline, Kaneka, Kawasumi Laboratories, Olympus Medical, Piolax Medical Devices, Sumitomo Bakelite, UMIDAS, and Zeon Medical; and contributions from Boston Scientific Japan, Gadelius Medical, Japan Lifeline, and Zeon Medical. Y. Nakai: Research funding from Boston Scientific Japan, Century Medical, Fujifilm, Gadelius Medical, Hitachi Medical, HOYA Pentax Medical, Kaneka, and Medico's Hirata; and honoraria from Boston Scientific Japan, Fujifilm, Gadelius Medical, Hitachi Medical, J-MIT, Medico's Hirata, and Olympus Medical. This work was not supported by any of those companies. All other authors disclosed no financial relationships. This work was supported by grants from the Japanese Foundation for Research and Promotion of Endoscopy (to T. Saito and Y. Nakai). T. Hamada was supported by a KAKENHI grant from Japan Society for the Promotion of Science (JP22H02841) and by grants from Takeda Science Foundation and Daiichi Sankyo Company. The funders had no role in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.

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