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. 2025 Dec;57(1):2546681.
doi: 10.1080/07853890.2025.2546681. Epub 2025 Aug 21.

Diagnosis, treatment and clinical outcomes of extrauterine sites of leiomyomatosis: a systematic review

Jacopo Di Giuseppe  1 , Leonardo Natalini  1 , Mila Bordini  1 , Daniele Crescenzi  1 , Linda Grementieri  1 , Jessica Petrucci  1 , Arianna Asaro  1 , Luca Giannella  1 , Giovanni Delli Carpini  1 , Camilla Grelloni  1 , Andrea Ciavattini  1
Affiliations

Diagnosis, treatment and clinical outcomes of extrauterine sites of leiomyomatosis: a systematic review

Jacopo Di Giuseppe et al. Ann Med. 2025 Dec.

Abstract

Background: This review aims to provide a comprehensive description of the clinical presentation, treatment, and histopathological features of extrauterine sites of leiomyomatosis (ESL), such as disseminated peritoneal leiomyomatosis (DPL), parasitic myoma (PM), benign metastatic leiomyoma (BML), and intravascular leiomyoma (IVL). The impact of previous surgery (hysterectomy or myomectomy) on development of intra-abdominal extrauterine leiomyomas (IAELs) and extra-abdominal extrauterine leiomyomas (EAELs) has been evaluated.

Methods: According to PRISMA guidelines, we searched PubMed, Scopus, and Web of Science databases. Relevant articles were retrieved in full-text format and screened based on predefined inclusion and exclusion criteria.

Results: 358 studies (372 cases) are included. Among IAELs, the most common symptom is abdominopelvic pain (63.9% of DPL, and 69.2% of PMs cases, respectively). In contrast, EAELs exhibit heterogeneous clinical presentations; dyspnea is the most common symptom (29.7% of BML, and 29.9% of IVL cases, respectively). 68.8% of DPL, 60% of PM, 89.7% of BML, and 56.4% of IVL patients underwent previous uterine surgery. A significant association (p = 0.0417) between the type of previous uterine surgery (hysterectomy and myomectomy) and the subsequent location of ESLs is found (68.7% VS 51.4% in EAELs, 31.3% VS 48.6% in IAELs, respectively).

Conclusions: DPL, PM, BML, and IVL exhibit overlapping characteristics, requiring a multimodal approach that includes imaging, histopathology, and surgical or medical management. Greater awareness among clinicians is needed regarding surgical procedures involving ligation and/or cutting of major uterine vessels, which appear to contribute to the development of EAELs, and morcellation, which tends to promote intraperitoneal metastatic spread.

Keywords: Hysterectomy; Leiomyoma; laparoscopy; laparotomy; morcellation; myomectomy.

Plain language summary

Disseminated peritoneal leiomyomatosis, parasitic myoma, benign metastatic leiomyoma, and intravascular leiomyoma represent a continuum of extrauterine sites of leiomyomatosis with overlapping but distinct features, requiring careful diagnostic differentiation.While surgical excision remains the mainstay, an integrated approach including imaging, histopathology, and medical-surgical management is essential for optimal patient outcomes.

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Conflict of interest statement

All authors know and comply with the Journal’s Conflict of Interest Policy. The present article is not under consideration for publication elsewhere. No conflicts of interest are declared. No sources of financial support are declared.

Figures

Figure 1.
Figure 1.
Literature review flow chart.
See this image and copyright information in PMC

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