Differential Cell-Specific, Regulatory Roles of Fc γ Receptor IIB through IgG in IgA Nephropathy

Tzu-Yu Liu¹, Chia-Chao Wu², Xiaorui Chen³, Chih-Chien Sung², Yu-Ling Chou¹, Feng-Cheng Liu⁴, Dimitra Lamprinaki⁵, Shun-Min Yang⁶, Chih-Ying Wu⁷, Yu-Ling Tsai^{8

9}, Wei-Ting Wong¹⁰, Norihito Kawasaki¹¹, Kuo-Feng Hua^{10

12}, Cheng-Hsu Chen^{13

14

15

16}, Ann Chen^{3

17

18}, Shuk-Man Ka¹⁹

Affiliations

¹ Graduate Institute of Life Sciences, National Defense Medical University, Taipei, Taiwan.
² Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
³ Department of Pathology, Hualien Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
⁴ Division of Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
⁵ Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
⁶ Institute of Physics, Academia Sinica, Taipei, Taiwan.
⁷ Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
⁸ School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
⁹ Department of Pathology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
¹⁰ Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
¹¹ Food & Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
¹² Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
¹³ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
¹⁴ Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹⁵ Ph.D. Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
¹⁶ Department of Life Science, Tunghai University, Taichung, Taiwan.
¹⁷ Taiwan Autoantibody Biobank Initiative, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
¹⁸ Graduate Institute of Medical Sciences, National Defense Medical University, Taipei, Taiwan.
¹⁹ Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical University, Taipei, Taiwan.

PMID: 40839400
DOI: 10.1681/ASN.0000000835

Differential Cell-Specific, Regulatory Roles of Fc γ Receptor IIB through IgG in IgA Nephropathy

Tzu-Yu Liu et al. J Am Soc Nephrol. 2025.

. 2025 Aug 21.

doi: 10.1681/ASN.0000000835. Online ahead of print.

Authors

Affiliations

¹ Graduate Institute of Life Sciences, National Defense Medical University, Taipei, Taiwan.
² Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
³ Department of Pathology, Hualien Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
⁴ Division of Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
⁵ Gut Microbes and Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
⁶ Institute of Physics, Academia Sinica, Taipei, Taiwan.
⁷ Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
⁸ School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.
⁹ Department of Pathology, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
¹⁰ Biotechnology and Animal Science, National Ilan University, Ilan, Taiwan.
¹¹ Food & Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
¹² Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
¹³ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
¹⁴ Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹⁵ Ph.D. Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
¹⁶ Department of Life Science, Tunghai University, Taichung, Taiwan.
¹⁷ Taiwan Autoantibody Biobank Initiative, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
¹⁸ Graduate Institute of Medical Sciences, National Defense Medical University, Taipei, Taiwan.
¹⁹ Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical University, Taipei, Taiwan.

PMID: 40839400
DOI: 10.1681/ASN.0000000835

No abstract available

Keywords: GN; IgA nephropathy; signaling.

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References

1. Gharavi AG, Yan Y, Scolari F, et al. IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat Genet. 2000;26(3):354–357. doi: 10.1038/81677 - DOI
1. Jarrick S, Lundberg S, Welander A, et al. Mortality in IgA nephropathy: a nationwide population-based cohort study. J Am Soc Nephrol. 2019;30(5):866–876. doi: 10.1681/ASN.2018101017 - DOI
1. Stamellou E, Seikrit C, Tang SCW, et al. IgA nephropathy. Nat Rev Dis Primers. 2023;9(1):67. doi: 10.1038/s41572-023-00476-9 - DOI
1. Cheung CK, Alexander S, Reich HN, Selvaskandan H, Zhang H, Barratt J. The pathogenesis of IgA nephropathy and implications for treatment. Nat Rev Nephrol. 2025;21(1):9–23. doi: 10.1038/s41581-024-00885-3 - DOI
1. Tringali E, Vetrano D, Tondolo F, et al. Role of serum complement C3 and C4 on kidney outcomes in IgA nephropathy. Sci Rep. 2024;14(1):16224. doi: 10.1038/s41598-024-65857-w - DOI

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Differential Cell-Specific, Regulatory Roles of Fc γ Receptor IIB through IgG in IgA Nephropathy

Affiliations

Differential Cell-Specific, Regulatory Roles of Fc γ Receptor IIB through IgG in IgA Nephropathy

Authors

Affiliations

References

Grants and funding

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Full Text Sources

Miscellaneous