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Comment
. 2025 Aug 21;22(8):e1004723.
doi: 10.1371/journal.pmed.1004723. eCollection 2025 Aug.

Cardiovascular-kidney-metabolic syndrome: A new frontier or simple rebranding?

Jennifer Manne-Goehler  1   2 , Willem Daniel Francois Venter  3 , Mohammed K Ali  4   5 , Juan V A Franco  6
Affiliations
Comment

Cardiovascular-kidney-metabolic syndrome: A new frontier or simple rebranding?

Jennifer Manne-Goehler et al. PLoS Med. .

Abstract

Cardiovascular-kidney-metabolic (CKM) syndrome is an emerging framework proposed by the American Heart Association for management of patients with cardio-metabolic multimorbidity. This novel framework offers several improvements over existing paradigms; however, it remains unclear whether it represents a new frontier, or a simple rebranding of known clinical principles.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The pathophysiology of cardiovascular-kidney-metabolic (CKM) syndrome.
Schematic showing the CKM health framework as proposed by the AHA [2]. Dysfunctional adipose tissue is an important underlying factor in the pathophysiology of CKM syndrome, eventually leading to derangement in these organ systems.
See this image and copyright information in PMC

Comment on

References

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