Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2025 Aug 21;389(6762):782-783.
doi: 10.1126/science.aea5377. Epub 2025 Aug 21.

A protein tunnel helps stressed lysosomes swell

Jennifer Lippincott-Schwartz  1
Affiliations
Comment

A protein tunnel helps stressed lysosomes swell

Jennifer Lippincott-Schwartz. Science. .

Abstract

The endoplasmic reticulum donates lipids through a tunnel-like protein to help lysosomes expand.

PubMed Disclaimer

Comment on

  • LYVAC/PDZD8 is a lysosomal vacuolator.
    Yang H, Xun J, Li Y, Mondal A, Lv B, Watkins SC, Shi L, Tan JX. Yang H, et al. Science. 2025 Aug 21;389(6762):eadz0972. doi: 10.1126/science.adz0972. Epub 2025 Aug 21. Science. 2025. PMID: 40839735 Free PMC article.

Substances

LinkOut - more resources