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Review
. 2025 Aug;7(5):514-517.
doi: 10.1016/j.jaccao.2025.05.016.

Cancer Development in Atherosclerotic Cardiovascular Disease: JACC: CardioOncology Short-Form Primer

Jessie M Dalman  1 , Kathryn J Moore  2
Affiliations
Review

Cancer Development in Atherosclerotic Cardiovascular Disease: JACC: CardioOncology Short-Form Primer

Jessie M Dalman et al. JACC CardioOncol. 2025 Aug.
No abstract available

Keywords: atherosclerosis; cardiovascular disease; coronary artery disease; epigenetics; heart failure; myocardial infarction; neoplasm; reverse cardio-oncology; tumor.

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Conflict of interest statement

Funding Support and Author Disclosures The authors were supported by grants from the Sarnoff Cardiovascular Research Foundation (to Ms Dalman) and the National Institutes of Health (R01HL172335, R01HL172365, and P01HL131481 to Dr Moore). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract
Figure 1
Figure 1
Cancer Development in Atherosclerotic CVD Cancer development in the context of cardiovascular disease (CVD) is driven by shared risk factors (top right) and molecular mechanisms identified in in human cohorts and preclinical animal models (top left). There may be a role for augmented surveillance protocols (bottom left) to monitor cancer survivors for the development of CVD, as well as to screen CVD patients for new cancer diagnoses. While no therapies have been specifically approved for these bidirectional cardio-oncologic treatment paradigms, existing therapies (bottom right) may target the mechanistic pathways contributing to cancer progression in the setting of CVD.
See this image and copyright information in PMC

References

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