Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2025 Aug;7(5):624-626.
doi: 10.1016/j.jaccao.2025.04.004.

Lowering Blood Pressure, Raising Cancer Risk?: Evidence From Randomized Clinical Trials and Genetic Studies

Affiliations
Editorial

Lowering Blood Pressure, Raising Cancer Risk?: Evidence From Randomized Clinical Trials and Genetic Studies

Fahmida Mannan et al. JACC CardioOncol. 2025 Aug.
No abstract available

Keywords: epidemiology; genetics; hypertension; ischemic disease; lifestyle risk factors; lung cancer; prevention; renal cell cancer.

PubMed Disclaimer

Conflict of interest statement

Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Figures

None
Graphical abstract

Comment on

  • doi: 10.1016/j.jaccao.2025.03.005

References

    1. Copland E., Canoy D., Nazarzadeh M., et al. Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis. Lancet Oncol. 2021;22:558–570. - PMC - PubMed
    1. Nazarzadeh M., Copland E., Smith Byrne K., et al. Blood pressure-lowering and risk of cancer: individual participant-level data meta-analysis and Mendelian randomization studies. JACC CardioOncol. 2025;7(5):609–623. - PMC - PubMed
    1. Sipahi I., Debanne S.M., Rowland D.Y., Simon D.I., Fang J.C. Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol. 2010;11:627–636. - PMC - PubMed
    1. Chan I.I., Kwok M.K., Schooling C.M. Blood pressure and risk of cancer: a Mendelian randomization study. BMC Cancer. 2021;21:1338. - PMC - PubMed
    1. Davies N.M., Holmes M.V., Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362

Publication types

LinkOut - more resources