doi: 10.1016/s0163-1047(85)90616-8.
Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats
- PMID: 4084181
- DOI: 10.1016/s0163-1047(85)90616-8
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Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats
Behav Neural Biol.
1985 Nov.
Abstract
The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.
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