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. 1985 Nov 15;232(1):211-5.
doi: 10.1042/bj2320211.

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

I R Batty, S R Nahorski, R F Irvine

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

I R Batty et al. Biochem J. .

Abstract

Carbachol stimulation of muscarinic receptors in rat cortical slices prelabelled with myo-[2-3H]inositol caused the rapid formation of a novel inositol polyphosphate. Evidence derived from its chromatographic behaviour, and from the structure of the products formed in partial dephosphorylation experiments, suggests that it is probably D-myo-inositol 1,3,4,5-tetrakisphosphate. An enzyme in human red cell membranes specifically removes the 5-phosphate from it to form inositol 1,3,4-trisphosphate. It is suggested that inositol 1,3,4,5-tetrakisphosphate is likely to be a second messenger, and that it is the precursor of inositol 1,3,4-trisphosphate and possibly of inositol 1,4,5-trisphosphate.

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References

    1. Biochim Biophys Acta. 1965 Jun 1;98(3):574-81 - PubMed
    1. Biochim Biophys Acta. 1963 Aug 27;70:474-6 - PubMed
    1. Biochem J. 1981 Apr 1;195(1):301-6 - PubMed
    1. Philos Trans R Soc Lond B Biol Sci. 1981 Dec 18;296(1080):123-38 - PubMed
    1. Biochem J. 1982 Apr 1;203(1):169-77 - PubMed

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