Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;44(10):1553-5.

[Effect of naloxone on the blood pressure response to tilting on spontaneously hypertensive rats]

[Article in German]
H J Seehrich, P Oehme
  • PMID: 4084259

[Effect of naloxone on the blood pressure response to tilting on spontaneously hypertensive rats]

[Article in German]
H J Seehrich et al. Biomed Biochim Acta. 1985.

Abstract

The influence of naloxone on the blood pressure response to tilting was studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). At the age of 5 weeks there were no significant differences in baseline blood pressure or the blood pressure response to tilting between both strains. After pretreatment with naloxone (0.4 mg/kg) there was a significantly higher increase of blood pressure due to tilting in SHR than in WKY rats. At the age of 26 weeks when in SHR the hypertension was fully developed the blood pressure response to tilting was significantly different from that in WKY rats and pretreatment with naloxone had no longer any influence. These results suggest a possible role of endogenous opiates in the development of hypertension.

PubMed Disclaimer

Publication types