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. 1985 Dec 17;133(2):554-62.
doi: 10.1016/0006-291x(85)90942-8.

Primary structure of bovine brain acidic fibroblast growth factor (FGF)

F Esch, N Ueno, A Baird, F Hill, L Denoroy, N Ling, D Gospodarowicz, R Guillemin

Primary structure of bovine brain acidic fibroblast growth factor (FGF)

F Esch et al. Biochem Biophys Res Commun. .

Abstract

The major anionic mitogenic polypeptide for endothelial cells, acidic fibroblast growth factor (FGF), has been purified to homogeneity from bovine brain and its complete primary structure established by gas-phase sequence analysis. The 140 amino acid (Mr 16,000) protein has been previously shown to be a potent growth factor for many diverse cell types of mesodermal origin, in vitro, and an angiogenic agent, in vivo. The amino acid sequence of bovine brain acidic FGF has a 53% absolute homology with that of bovine pituitary basic FGF suggesting that these endothelial cell mitogens are derived from a single ancestral gene.

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