Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Sep;25(9):382-389.
doi: 10.1016/j.bjae.2025.06.001. Epub 2025 Jul 16.

Acute-on-chronic liver failure

K G Rodgers  1 , R Swann  1 , R Hart  1
Affiliations
Review

Acute-on-chronic liver failure

K G Rodgers et al. BJA Educ. 2025 Sep.
No abstract available

Keywords: acute-on-chronic liver failure; cirrhosis; hepatic insufficiency; liver failure.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

    1. Moreau R., Jalan R., Gines P., et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144:1426–1437. - PubMed
    1. European Association for the Study of the Liver EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69:406–460. - PubMed
    1. EASL Clinical Practice Guidelines on acute-on-chronic liver failure. J Hepatol. 2023;79:461–491. - PubMed
    1. Clara J., Stauber R.E., Coenraad M.J., et al. Systemic inflammation in decompensated cirrhosis: characterization and role in acute-on-chronic liver failure. Hepatology. 2016;64:1249–1264. - PubMed
    1. Martin-Mateos R., Alvarez-Mon M., Albillos A. Dysfunctional immune response in acute-on-chronic liver failure: it takes two to tango. Front Immunol. 2019;10:973. - PMC - PubMed

LinkOut - more resources