Bowel preparation quality in patients using glucagon-like peptide-1 agonists: a systematic review and meta-analysis

Abstract

Background and aims: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are now the mainstay treatment for many chronic conditions, including diabetes mellitus, obesity, heart failure, and chronic kidney disease. GLP-1 RAs may affect bowel preparation for a colonoscopy by modifying intestinal motility and gastric emptying. We conducted a systematic review and meta-analysis to investigate the impact of GLP-1 RA use on bowel preparation quality, measured by the Boston Bowel Preparation Scale, and the frequency of inadequate preparation events.

Methods: Multiple databases were searched for studies investigating the impact of GLP-1 RA on bowel preparation for colonoscopy. Primary end points included bowel preparation quality, measured by the Boston Bowel Preparation Scale (BBPS), and the frequency of inadequate preparation events. Random-effects model was used for statistical analysis.

Results: Six studies were included in the final meta-analysis. There was no significant difference in the pooled rate of inadequate bowel preparation events between the GLP-1 RA group and the control group (odds ratio, 1.00; 95% CI, 0.73-1.37; P = .99; I² = 33%). Mean BBPS score reported in 3 studies was significantly lower in the GLP-1 RA group (mean difference, -0.36; 95% CI, 0.44 to -0.28; P < .001; I² = 91%).

Conclusions: GLP-1 RA use does not impact bowel preparation for colonoscopy as evident by our study. We do not recommend discontinuing GLP-1 RAs before colonoscopy. More evidence is needed to confirm the current findings.