Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Sep;603(17):4911-4912.
doi: 10.1113/JP289732. Epub 2025 Aug 22.

Muscle spectrin

Affiliations

Muscle spectrin

Matthew N Rasband et al. J Physiol. 2025 Sep.
No abstract available

Keywords: cytoskeleton; muscle; neuromuscular junction.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.. Spectrin gene expression in human muscle.
Transcripts per million (TPM) measured from 818 samples. Data from GTEx project.

Comment on

References

    1. Buelow M, Sussmuth D, Smith LD, Aryani O, Castiglioni C, Stenzel W, Bertini E, Schuelke M & Knierim E. (2021). Novel bi-allelic variants expand the SPTBN4-related genetic and phenotypic spectrum. Eur J Hum Genet 29, 1121–1128. - PMC - PubMed
    1. De Winter J, Palmio J, Schuelke M, Udd B, Stenzel W & Baets J. (2025a). Loss-of-function variants in SPTAN1 and SPTBN4 cause early-onset hereditary myopathy. J Physiol (Lond) in press. - PubMed
    1. De Winter J, Van de Vondel L, Ermanoska B, Monticelli A, Isapof A, Cohen E, Stojkovic T, Hackman P, Johari M, Palmio J, Waldrop MA, Meyer AP, Nicolau S, Flanigan KM, Topf A, Diaz-Manera J, Straub V, Longman C, McWilliam CA, Orbach R, Verma S, Laine R, Donkervoort S, Bonnemann CG, Rebelo A, Zuchner S, Grider T, Shy ME, Maystadt I, Demurger F, Cairns A, Beecroft S, Folland C, De Ridder W, Ravenscroft G, Bonne G, Udd B & Baets J. (2025b). Heterozygous loss-of-function variants in SPTAN1 cause an early childhood onset distal myopathy. Genetics in medicine : official journal of the American College of Medical Genetics 27, 101399. - PubMed
    1. Ho TS, Zollinger DR, Chang KJ, Xu M, Cooper EC, Stankewich MC, Bennett V & Rasband MN. (2014). A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci 17, 1664–1672. - PMC - PubMed
    1. Huang CY, Zhang C, Ho TS, Oses-Prieto J, Burlingame AL, Lalonde J, Noebels JL, Leterrier C & Rasband MN. (2017a). alphaII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. J Neurosci 37, 11311–11322. - PMC - PubMed

LinkOut - more resources