[3H]dexamethasone binding in the limbic brain of the fetal rat

Abstract

The pituitary-adrenal system in the fetal rat is relatively well-developed and during the later part of fetal life circulating corticosterone levels are comparable to those seen in adults. Shortly after birth the adrenal gland regresses and corticosterone levels decrease dramatically. In this paper we report evidence for a similar developmental pattern for the glucocorticoid receptor system within the limbic brain. Thus, glucocorticoid receptor concentrations are higher during the fetal period than during early postnatal life. Moreover, the specificity and the affinity with which glucocorticoid receptors bind [3H]dexamethasone are, according to our data, indistinguishable from those found in the limbic brain of the adult rat.