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. 2025 Aug 20;41(8):711-724.
doi: 10.3760/cma.j.cn501225-20250426-00191.

[Clinical expert consensus on application of topical growth factors in chronic wounds (2025 edition)]

[Article in Chinese]
Chinese Burn Association; Editorial Committee of Chinese Journal of Burns and Wounds

[Clinical expert consensus on application of topical growth factors in chronic wounds (2025 edition)]

[Article in Chinese]
Chinese Burn Association et al. Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. .

Abstract
in English, Chinese

Chronic wounds refer to wounds that fail to achieve complete structural repair within the expected time frame despite standardized systemic treatment, which are characterized by high incidence, complex mechanisms, prolonged clinical course, and difficulty in treatment. Topical growth factor drugs or biological agents, which regulate cell proliferation, migration, and differentiation, thereby effectively promoting the wound healing process, are widely used in the repair of various acute and chronic wounds. However, there is still some controversy over the application of topical growth factors in the clinical practice of treating various chronic wounds. Chinese Burn Association and Editorial Committee of Chinese Journal of Burns and Wounds jointly initiated and organized a multidisciplinary expert group. Based on current evidence-based medical evidence, clinical practice, and authoritative guidelines from other disciplines, this clinical expert consensus was developed for further standardization of the application of topical growth factors in the clinical treatment of chronic wounds.

慢性创面是指经过规范系统治疗，而未能在一定预期时间内实现组织结构完全修复的创面，其具有发病率高、机制复杂、病程迁延、治疗难度大的特点。外用生长因子类药物或生物制剂具有调控细胞增殖、迁移和分化等作用，可有效促进创面愈合进程，已被广泛应用于各类急、慢性创面的修复中。但在各类慢性创面治疗的临床实践中，对于外用生长因子类制剂的应用策略尚存在较多争议。因此，中华医学会烧伤外科学分会、《中华烧伤与创面修复杂志》编辑委员会共同发起并组织多学科专家，基于目前的循证医学证据、临床实践和其他学科临床指南，制订该临床专家共识，旨在进一步规范外用生长因子类制剂在慢性创面临床治疗中的应用。.

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Conflict of interest statement

利益冲突 所有编写组成员声明不存在利益冲突，无商业组织向本共识编写组支付费用。本共识制订过程中需要的资金均来自本文著录的基金项目，用以承担制订过程中的科研费及项目组织实施等费用，且推荐意见未受资助影响

Figures

图 1
图 1
《慢性创面外用生长因子的临床专家共识（2025版）》专家推荐意见流程图 Recommendation flow chart of Clinical expert consensus on application of topical growth factors in chronic wounds (2025 edition)
See this image and copyright information in PMC

References

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