[Interpretation of the 2023 International Society for Burn Injuries "Surviving Sepsis After Burn Campaign"]

Abstract

The Surviving Sepsis After Burn Campaign published by the International Society for Burn Injuries in 2023, are the first international guidelines for the management of sepsis in burn patients. The guidelines systematically integrate the strategies for the diagnosis, prevention, and treatment of burn sepsis for the first time, encompassing the whole processes of sepsis management from early warning indicators (such as dynamic changes in sepsis-related organ failure assessment scores and procalcitonin trends) to personalized interventions (such as wound management and antibiotic de-escalation therapy). More importantly, the guidelines emphasize an organ function-oriented dynamic assessment framework, breaking through the limitations of traditional biomarkers and put forward innovative recommendations specifically for the hypermetabolic state, wound infections, and risks of multidrug-resistant organisms infections uniquely associated with burn sepsis. Based on the progress of international research on burn sepsis, this article provides an in-depth analysis of the guidelines' key points, offering evidence-based insights for clinical practice.