Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2025 May 20;87(7):4632-4635.
doi: 10.1097/MS9.0000000000003416. eCollection 2025 Jul.

Acute neurological decline in Fahr's syndrome: a rare case suggesting viral illness as a potential trigger

Muhammad Nawaz Khan  1 , Iman Muhammad Tahir  1 , Manal Arshad Malik  1 , Ahsan Ali Jafri  1 , Syed Muhammad Sinaan Ali  1 , Md Ariful Haque  2   3
Affiliations
Case Reports

Acute neurological decline in Fahr's syndrome: a rare case suggesting viral illness as a potential trigger

Muhammad Nawaz Khan et al. Ann Med Surg (Lond). .

Abstract

Introduction and importance: Fahr's syndrome is a rare neurodegenerative disorder characterized by bilateral intracranial calcifications, primarily affecting the basal ganglia, thalamus, and cerebellum. It presents with a wide range of neurological and psychiatric symptoms, often mimicking more common conditions.

Case presentation: We report the case of a 45-year-old South Asian male with no known comorbidities who presented with acute fever, altered consciousness, and generalized tonic-clonic seizures. Initial management targeted a suspected central nervous system infection, but neuroimaging revealed bilateral basal ganglia calcifications.

Clinical discussion: Extensive metabolic and infectious workups were unremarkable, leading to a diagnosis of Fahr's syndrome through multidisciplinary evaluation. Genetic testing was not performed due to financial constraints. The patient showed significant improvement with empirical anticonvulsant therapy and supportive care and was advised outpatient follow-up.

Conclusion: This case emphasizes the importance of considering Fahr's syndrome in patients presenting with unexplained neurological symptoms, particularly in resource-limited settings where access to genetic testing is restricted. Early recognition through neuroimaging is crucial to avoid misdiagnosis and ensure appropriate management. Increased awareness among clinicians is necessary for timely intervention and improved patient outcomes.

Keywords: Fahr syndrome; calcification; case report; neurodegenerative disease; seizures.

PubMed Disclaimer

Conflict of interest statement

Not applicable.

Figures

Figure 1.
Figure 1.
Axial T1-weighted images (A, B) show symmetrical signal changes in the basal ganglia, particularly in the putamen and caudate nuclei. Coronal T1-weighted images (C, D) further highlight the involvement of the globus pallidus and thalamus. Axial T2-weighted images (E, F) demonstrate hyperintense signals in the putamen, caudate nuclei, and thalamus.
Figure 2.
Figure 2.
Axial non-contrast CT brain showing bilateral basal ganglia hyperdensities.
See this image and copyright information in PMC

References

    1. Saleem S, Aslam HM, Anwar M, et al. Fahr’s syndrome: literature review of current evidence. Orphanet J Rare Dis 2013;8:156. - PMC - PubMed
    1. Perugula ML, Lippmann S. Fahr’s disease or Fahr’s syndrome? ICNS 2016;13:45–46. - PMC - PubMed
    1. Manyam PB, Bilateral striopallidodentate calcinosis Orphanet: Orphanet; 2010. https://www.orpha.net/en/disease/detail/1980%20[Internet].%20Bilateral%2...
    1. Amisha F, Munakomi SFS. StatPearls. Treasure Island (FL) Ineligible Companies. StatPearls Publishing; 2023.
    1. Manyam BV, Walters AS, Narla KR. Bilateral striopallidodentate calcinosis: clinical characteristics of patients seen in a registry. J Mov Disord Soc 2001;16:258–64. - PubMed

Publication types

LinkOut - more resources