Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 May 30;87(7):4344-4355.
doi: 10.1097/MS9.0000000000003451. eCollection 2025 Jul.

Prostate cancer risk reduction: promising prevention practices and insights

Emmanuel Ifeanyi Obeagu  1
Affiliations
Review

Prostate cancer risk reduction: promising prevention practices and insights

Emmanuel Ifeanyi Obeagu. Ann Med Surg (Lond). .

Abstract

Prostate cancer is among the leading causes of cancer-related morbidity and mortality in men worldwide. Despite advancements in diagnostic and therapeutic approaches, prevention remains a critical strategy to curb its prevalence. This review examines promising prevention practices, including lifestyle modifications, dietary interventions, and the use of chemopreventive agents. It also delves into emerging insights from genetic, epigenetic, and molecular studies, offering a comprehensive framework for reducing prostate cancer risk through tailored and evidence-based approaches. Lifestyle changes, such as maintaining a healthy weight, engaging in regular physical activity, and adopting a plant-based diet, have shown substantial potential in mitigating prostate cancer risk. Specific dietary components, like antioxidants found in fruits and vegetables and omega-3 fatty acids in fish, demonstrate protective properties, while reducing the intake of red and processed meats is encouraged. Chemopreventive agents, including 5-alpha reductase inhibitors and anti-inflammatory medications, offer additional strategies but require careful assessment of risks and benefits.

Keywords: lifestyle modifications; nutritional strategies; prevention; prostate cancer; risk reduction.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Similar articles

  • Prescription of Controlled Substances: Benefits and Risks.
    Preuss CV, Kalava A, King KC. Preuss CV, et al. 2025 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2025 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 30726003 Free Books & Documents.
  • Management of urinary stones by experts in stone disease (ESD 2025).
    Papatsoris A, Geavlete B, Radavoi GD, Alameedee M, Almusafer M, Ather MH, Budia A, Cumpanas AA, Kiremi MC, Dellis A, Elhowairis M, Galán-Llopis JA, Geavlete P, Guimerà Garcia J, Isern B, Jinga V, Lopez JM, Mainez JA, Mitsogiannis I, Mora Christian J, Moussa M, Multescu R, Oguz Acar Y, Petkova K, Piñero A, Popov E, Ramos Cebrian M, Rascu S, Siener R, Sountoulides P, Stamatelou K, Syed J, Trinchieri A. Papatsoris A, et al. Arch Ital Urol Androl. 2025 Jun 30;97(2):14085. doi: 10.4081/aiua.2025.14085. Epub 2025 Jun 30. Arch Ital Urol Androl. 2025. PMID: 40583613 Review.
  • Hail Lifestyle Medicine consensus position statement as a medical specialty: Middle Eastern perspective.
    Alrajhi S, Konswa AA, Alhamdi N, Alshammari F, Alqurashi A, Alraddadi R, Alfheeaid H, Albattal S, Alsoqih N, Almuhaileb F, Alnais M, Kunonga E, Latif S, Tanigawa Guimaraes S, Tariq R, Albishri T, Alrasadi K. Alrajhi S, et al. Front Public Health. 2025 Jun 20;13:1455871. doi: 10.3389/fpubh.2025.1455871. eCollection 2025. Front Public Health. 2025. PMID: 40620567 Free PMC article.
  • Strategies for enhancing the implementation of school-based policies or practices targeting risk factors for chronic disease.
    Wolfenden L, Nathan NK, Sutherland R, Yoong SL, Hodder RK, Wyse RJ, Delaney T, Grady A, Fielding A, Tzelepis F, Clinton-McHarg T, Parmenter B, Butler P, Wiggers J, Bauman A, Milat A, Booth D, Williams CM. Wolfenden L, et al. Cochrane Database Syst Rev. 2017 Nov 29;11(11):CD011677. doi: 10.1002/14651858.CD011677.pub2. Cochrane Database Syst Rev. 2017. Update in: Cochrane Database Syst Rev. 2022 Aug 29;8:CD011677. doi: 10.1002/14651858.CD011677.pub3. PMID: 29185627 Free PMC article. Updated.
  • Selenium for preventing cancer.
    Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Crespi CM. Vinceti M, et al. Cochrane Database Syst Rev. 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4. Cochrane Database Syst Rev. 2018. PMID: 29376219 Free PMC article.
See all similar articles

References

    1. Obeagu EI. Prevention and early detection of prostate cancer. Int J Curr Res Med Sci 2023;9:20–24.
    1. Obeagu EI, Amilo GI, Obeagu GU, et al. Evaluation of impact of level of prostate specific antigen on haematological parameters of men in Owerri, Nigeria. J Biomed Sci Appl 2017;1:3.
    1. Obeagu EI, Awil MA, Obeagu GU. Prostate cancer: prevention, risk factors, pathophysiology. J Biomed Innovation 2023;12:437–42.
    1. Ozims S, Agu G, Amah H, et al. Prevalence of prostate enlargement among males >50 years of age who were treated at Abia State University Teaching Hospital, Aba from 2010-2014. Int J Res Studies in Med Health Sci 2018;3:1–7.
    1. Nnatuanya IN, Obeagu EI, Nwakulite A, et al. Evaluation of C-reactive proteins in benign prostatic hyperplasia (BPH) subjects. Madonna University J Med Health Sci ISSN: 2814-3035 2022;2:239–48.

LinkOut - more resources