Phages infecting the pathobiont Escherichia coli LF82
- PMID: 40853019
- PMCID: PMC12509680
- DOI: 10.1128/mra.00581-25
Phages infecting the pathobiont Escherichia coli LF82
Abstract
Escherichia coli LF82 is a gut pathobiont commonly found in Crohn's disease patients and a candidate for phage therapy. We report isolation of lytic phages able to infect LF82, with 19 unique genome sequences falling into four species clusters.
Keywords: AIEC; Escherichia coli; bacteriophage; pathobiont.
Conflict of interest statement
The authors declare no conflict of interest.
References
- 
    - Federici S, Kredo-Russo S, Valdés-Mas R, Kviatcovsky D, Weinstock E, Matiuhin Y, Silberberg Y, Atarashi K, Furuichi M, Oka A, et al. 2022. Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation. Cell 185:2879–2898. doi: 10.1016/j.cell.2022.07.003 - DOI - PubMed
 
- 
    - Galtier M, De Sordi L, Sivignon A, de Vallée A, Maura D, Neut C, Rahmouni O, Wannerberger K, Darfeuille-Michaud A, Desreumaux P, Barnich N, Debarbieux L. 2017. Bacteriophages targeting adherent invasive Escherichia coli strains as a promising new treatment for Crohn’s disease. J Crohns Colitis 11:840–847. doi: 10.1093/ecco-jcc/jjw224 - DOI - PubMed
 
- 
    - Darfeuille-Michaud A, Neut C, Barnich N, Lederman E, Di Martino P, Desreumaux P, Gambiez L, Joly B, Cortot A, Colombel JF. 1998. Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn’s disease. Gastroenterology 115:1405–1413. doi: 10.1016/s0016-5085(98)70019-8 - DOI - PubMed
 
Grants and funding
LinkOut - more resources
- Full Text Sources
- Medical
 
        