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. 2025 Sep;35(3):e70062.
doi: 10.1111/jora.70062.

Mental health and substance use problems among adolescents in Lesotho: Prevalence, access to care, and association with lifestyle factors

Natalie E Johnson  1   2 , Irene Falgas-Bague  1   2   3 , Frédérique Chammartin  1   2 , Felix Gerber  1   2 , Tristan T Lee  1   2 , Ravi Gupta  4 , Relebohile Mjadu  4 , Jonase Nthunya  4 , Moleboheng Mokebe  4 , Retsélisitsoe Makabateng  4 , Mamoronts'ane P Sematle  4 , Pearl Letsoela  5 , Niklaus D Labhardt  1   2 , Alain Amstutz  1   2   6   7 , Jennifer M Belus  1   2
Affiliations

Mental health and substance use problems among adolescents in Lesotho: Prevalence, access to care, and association with lifestyle factors

Natalie E Johnson et al. J Res Adolesc. 2025 Sep.

Abstract

Adolescence is a developmental window in which mental health symptomatology and other health behaviors can set lifelong trajectories. Yet, adolescent development research in rural areas of low-resource communities is severely lacking. Conceptualized in the Adolescent Well-Being Framework, where diet and activity form a core domain of well-being, we examined two modifiable risk behaviors (sugar-sweetened beverage consumption and physical activity) and their associations with mental health and substance use problems among 1351 adolescents aged 10-17 years (51% girls) in a rural setting in Lesotho, southern Africa. Standardized screening measures showed at least one clinically relevant mental health problem among 3% of the overall sample and 5% among 15-17 year-olds. Among those in the overall sample meeting these criteria, 45% recognized a need for help, yet only 17% obtained any care, leaving an 83% treatment gap. After adjusting for age and sex, any sugar-sweetened beverage consumption was associated with having at least one mental health symptom or recent substance use and with clinically relevant mental health and substance use problems. Physical activity showed no significant associations. Although the overall prevalence of clinically relevant mental health and substance use problems was relatively low, low levels of problem awareness suggest a need for adolescent-appropriate demand-side interventions for early treatment. Future research may explore possible indigenous protective factors underlying the low prevalence and clarify the pathway between health behaviors and mental health problems.

Keywords: PTSD; adolescents; anxiety; depression; substance use; sugar‐sweetened beverages.

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Conflict of interest statement

The authors declare no competing interests.

Figures

FIGURE 1
FIGURE 1
Cascade of care for participants with clinically relevant mental health or substance use problems.
See this image and copyright information in PMC

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