. 2025 Aug 27;13(1):47.

doi: 10.1186/s40560-025-00816-9.

Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU)

Andrew Li^{1

2}, Prashant Nasa^{3

4}, Sheila Nainan Myatra⁵, Gentle Sunder Shrestha^{6

7}, Abdulrahman Al-Fares^{8

9}, Ming-Cheng Chan^{10

11

12}, Young-Jae Cho¹³, Moritoki Egi¹⁴, Mohammad Omar Faruq¹⁵, Carine Harmouche¹⁶, Seyed Mohammad Reza Hashemian¹⁷, Ayman Kharaba¹⁸, Aidos Konkayev^{19

20}, Faisal Muchtar²¹, Khalid Mahmood Khan Nafees²², Mendsaikhan Naranpurev²³, Do Ngoc Son^{24

25

26}, Pauline Yeung Ng^{27

28}, Mohd Basri Mat-Nor²⁹, Jose Emmanuel Palo³⁰, Mehmet Uyar³¹, Zhongheng Zhang³², Jigeeshu Divatia^{5

33}, Jason Phua^{34

35

36}, Yaseen M Arabi³⁷, Lowell Ling^{38

39}; ERA-ICU Study Group, the Asian Critical Care Clinical Trials Group

Collaborators, Affiliations

Collaborators

ERA-ICU Study Group, the Asian Critical Care Clinical Trials Group:
Ariful Basher, Mahbub Morshed, Tasmia Kashfi, Bin Lin, Chun Pan, Dechang Chen, Gang Wang, Jiao Liu, Lihui Wang, Ling-Ai Pan, Lining Si, Xu Wei, Yi Zhang, Yiping Wang, Yuetian Yu, Hoi Ping Shum, Kwok-Ming Ho, Man Yee Man, Wai-Tat Wong, Anirban Hom Choudhuri, Badri Prasad Das, Bharat G Jagiasi, Deepak Govil, Mehul Shah, Pravin Amin, Rajesh Mishra, Rajesh Mohan Shetty, Ravi Shankar, Shivangi Mishra, Simant Jha, Subhal Dixit, Swarna Deepak Kuragayala, R Vaidyanathan, Ziyokov Joshi, Erwin Pradian, Haizah Nurdin, Nurita Dian Kestriani Saragi Sitio, Hideto Yasuda, Kazuaki Atagi, Benazir Azimova, Maiya Konkayeva, Nursultan Dauletbaev, Dalal Aldosari, Sajida Sange, Zeina Aoun Bacha, Ji Zhang Chin, M Shanaz Hasan, Muhamad Hafizzi, Nor'azim Mohd Yunos, Zheng-Yii Lee, Enkhsaikhan Samdan, Erdenechimeg Tegshee, Suvd-Erdene Narmandakh, Tamir Lkhagvadorj, Telmen Amartur, Tsolmon Begzjav, Mahir AlBahrani, Ashok Kumar, Muhammad Sohaib, Muneeb Ali, Sheharyar Ashraf, Debbie Noblezada-Uy, Faith Joan Gaerlan, Gerardo Briones, Jeremiah Butch T Gemarino, Kevin De Asis, Marion Patricio, Pauline Convocar, Rodolfo Roman Bigornia, Byunghyuk Yu, Jae Kyeom Sim, Jongmin Lee, Jung-Min Bae, Kyoung Hoon Lim, Kyungsoo Chung, Soyoung Park, Sejoong Kim, Song I Lee, Won-Young Kim, Abdullah M Alhammad, Carlos Sanchez, Faten Farid Awdallah, Ghaleb Almekhlafi, Mohamed Hegazy, Mohammed Alshahrani, Rawah Shafiq Aljishi, Samiyah Alanazi, Zainab Al Duhailib, Amartya Mukhopadhyay, Balachandran Kayachandran, Charles Chin Han Lew, Clarabella Liew, Geetha Kayambu, John Tsoong, K Ramanathan, Kay Choong See, Kumaresh Venkatesan, Matthew Cove, Roshni Gokhale, Sharlene Ho, Shir Lynn Lim, Yew Woon Chia, Yi Hern Tan, Yie Hui Lau, Yu-Lin Wong, Will Loh, Cong-Tat Cia, Han-Chung Hu, Jia-Jun Wu, Jia-Yih Feng, Ming-Chieh Yang, Sheng-Yuan Ruan, Alaaeiden Ghanem, Imadeddin Barakat, Jihad Mallat, Rania Omar, Reda Mohamed Sherif, Binh Son Ha, Chinh Quoc Luong, Dai Quang Huynh, Hieu Huu Hoang, Huan Huu Nguyen, Hung Ngoc Dinh, Hung Tan Nguyen, Minh Hoa Le, Kien Trung Nguyen, Phuoc Thien Duong, Son Ngoc Do, Dung Tat Nguyen, Thai Van Hoang, Thao Thi Ngoc Pham, Thien Xuan Mai, Thuy Thi Phuong Le, To Dang Nguyen, Chinh Huy Vu

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
² Department of Intensive Care Medicine, Woodlands Health, Singapore, Singapore.
³ Critical Care Medicine, NMC Specialty Hospital, Dubai, United Arab Emirates.
⁴ Integrated Critical Care Unit, New Cross Hospital, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.
⁵ Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
⁶ Department of Critical Care Medicine, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Bagmati, Nepal.
⁷ Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
⁸ Department of Anesthesia, Critical Care Medicine, and Pain Medicine, Ministry of Health, Al-Amiri Hospital, Kuwait City, Kuwait.
⁹ Kuwait Extracorporeal Life Support Program, Al-Amiri Center for Respiratory and Cardiac Failure, Ministry of Health, Kuwait City, Kuwait.
¹⁰ Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹¹ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
¹² Division of Critical Care and Respiratory Therapy, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹³ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
¹⁴ Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan.
¹⁵ Department of Critical Care Medicine & Emergency Medicine, United Hospital, Dhaka, Bangladesh.
¹⁶ Pulmonary & Critical Care Division, Hotel Dieu de France, Saint Joseph University of Beirut, Beirut, Lebanon.
¹⁷ Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹⁸ Department of Critical Care, King Fahad Hospital, Al Madinah Al Monawarah, Saudi Arabia.
¹⁹ Anaesthesiology and Intensive Care Department, Astana Medical University, Astana, Kazakhstan.
²⁰ National Science Center of Traumatology and Orthopedia Named Batpenov, Astana, Kazakhstan.
²¹ Department of Anesthesiology, Intensive Care and Pain Management, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
²² Ministry of Health, Department of Critical Care Medicine, RIPAS Hospital, Bandar Seri Begawan, Brunei.
²³ Intensive Care Department, Mongolia Japan Hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
²⁴ Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.
²⁵ Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.
²⁶ Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.
²⁷ Critical Care Medicine Unit, The University of Hong Kong, Hong Kong SAR, China.
²⁸ Department of Adult Intensive Care, Queen Mary Hospital, Hong Kong SAR, China.
²⁹ Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
³⁰ Acute and Critical Care Institute, The Medical City, Pasig, Philippines.
³¹ Department of Anaesthesiology and Intensive Care Unit, Ege University School of Medicine Hospital, Izmir, Turkey.
³² Department of Emergency Medicine, Provincial Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³³ Critical Care Medicine, Lilavati Hospital and Research Centre, Mumbai, India.
³⁴ Division of Respiratory and Critical Care Medicine, Department of Medicine, Alexandra Hospital, National University Health System, Singapore, Singapore.
³⁵ Division of Respiratory and Critical Care Medicine, National University Hospital, National University Health System, Singapore, Singapore.
³⁶ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
³⁷ College of Medicine, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
³⁸ Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong SAR, China. lowell.ling@cuhk.edu.hk.
³⁹ Department of Intensive Care, Prince of Wales Hospital, Hong Kong SAR, China. lowell.ling@cuhk.edu.hk.

PMID: 40859362
PMCID: PMC12382108
DOI: 10.1186/s40560-025-00816-9

Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU)

Andrew Li et al. J Intensive Care. 2025.

. 2025 Aug 27;13(1):47.

doi: 10.1186/s40560-025-00816-9.

Authors

Collaborators

ERA-ICU Study Group, the Asian Critical Care Clinical Trials Group:
Ariful Basher, Mahbub Morshed, Tasmia Kashfi, Bin Lin, Chun Pan, Dechang Chen, Gang Wang, Jiao Liu, Lihui Wang, Ling-Ai Pan, Lining Si, Xu Wei, Yi Zhang, Yiping Wang, Yuetian Yu, Hoi Ping Shum, Kwok-Ming Ho, Man Yee Man, Wai-Tat Wong, Anirban Hom Choudhuri, Badri Prasad Das, Bharat G Jagiasi, Deepak Govil, Mehul Shah, Pravin Amin, Rajesh Mishra, Rajesh Mohan Shetty, Ravi Shankar, Shivangi Mishra, Simant Jha, Subhal Dixit, Swarna Deepak Kuragayala, R Vaidyanathan, Ziyokov Joshi, Erwin Pradian, Haizah Nurdin, Nurita Dian Kestriani Saragi Sitio, Hideto Yasuda, Kazuaki Atagi, Benazir Azimova, Maiya Konkayeva, Nursultan Dauletbaev, Dalal Aldosari, Sajida Sange, Zeina Aoun Bacha, Ji Zhang Chin, M Shanaz Hasan, Muhamad Hafizzi, Nor'azim Mohd Yunos, Zheng-Yii Lee, Enkhsaikhan Samdan, Erdenechimeg Tegshee, Suvd-Erdene Narmandakh, Tamir Lkhagvadorj, Telmen Amartur, Tsolmon Begzjav, Mahir AlBahrani, Ashok Kumar, Muhammad Sohaib, Muneeb Ali, Sheharyar Ashraf, Debbie Noblezada-Uy, Faith Joan Gaerlan, Gerardo Briones, Jeremiah Butch T Gemarino, Kevin De Asis, Marion Patricio, Pauline Convocar, Rodolfo Roman Bigornia, Byunghyuk Yu, Jae Kyeom Sim, Jongmin Lee, Jung-Min Bae, Kyoung Hoon Lim, Kyungsoo Chung, Soyoung Park, Sejoong Kim, Song I Lee, Won-Young Kim, Abdullah M Alhammad, Carlos Sanchez, Faten Farid Awdallah, Ghaleb Almekhlafi, Mohamed Hegazy, Mohammed Alshahrani, Rawah Shafiq Aljishi, Samiyah Alanazi, Zainab Al Duhailib, Amartya Mukhopadhyay, Balachandran Kayachandran, Charles Chin Han Lew, Clarabella Liew, Geetha Kayambu, John Tsoong, K Ramanathan, Kay Choong See, Kumaresh Venkatesan, Matthew Cove, Roshni Gokhale, Sharlene Ho, Shir Lynn Lim, Yew Woon Chia, Yi Hern Tan, Yie Hui Lau, Yu-Lin Wong, Will Loh, Cong-Tat Cia, Han-Chung Hu, Jia-Jun Wu, Jia-Yih Feng, Ming-Chieh Yang, Sheng-Yuan Ruan, Alaaeiden Ghanem, Imadeddin Barakat, Jihad Mallat, Rania Omar, Reda Mohamed Sherif, Binh Son Ha, Chinh Quoc Luong, Dai Quang Huynh, Hieu Huu Hoang, Huan Huu Nguyen, Hung Ngoc Dinh, Hung Tan Nguyen, Minh Hoa Le, Kien Trung Nguyen, Phuoc Thien Duong, Son Ngoc Do, Dung Tat Nguyen, Thai Van Hoang, Thao Thi Ngoc Pham, Thien Xuan Mai, Thuy Thi Phuong Le, To Dang Nguyen, Chinh Huy Vu

Affiliations

¹ Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
² Department of Intensive Care Medicine, Woodlands Health, Singapore, Singapore.
³ Critical Care Medicine, NMC Specialty Hospital, Dubai, United Arab Emirates.
⁴ Integrated Critical Care Unit, New Cross Hospital, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.
⁵ Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
⁶ Department of Critical Care Medicine, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Bagmati, Nepal.
⁷ Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
⁸ Department of Anesthesia, Critical Care Medicine, and Pain Medicine, Ministry of Health, Al-Amiri Hospital, Kuwait City, Kuwait.
⁹ Kuwait Extracorporeal Life Support Program, Al-Amiri Center for Respiratory and Cardiac Failure, Ministry of Health, Kuwait City, Kuwait.
¹⁰ Department of Critical Care Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹¹ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.
¹² Division of Critical Care and Respiratory Therapy, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
¹³ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
¹⁴ Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan.
¹⁵ Department of Critical Care Medicine & Emergency Medicine, United Hospital, Dhaka, Bangladesh.
¹⁶ Pulmonary & Critical Care Division, Hotel Dieu de France, Saint Joseph University of Beirut, Beirut, Lebanon.
¹⁷ Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹⁸ Department of Critical Care, King Fahad Hospital, Al Madinah Al Monawarah, Saudi Arabia.
¹⁹ Anaesthesiology and Intensive Care Department, Astana Medical University, Astana, Kazakhstan.
²⁰ National Science Center of Traumatology and Orthopedia Named Batpenov, Astana, Kazakhstan.
²¹ Department of Anesthesiology, Intensive Care and Pain Management, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia.
²² Ministry of Health, Department of Critical Care Medicine, RIPAS Hospital, Bandar Seri Begawan, Brunei.
²³ Intensive Care Department, Mongolia Japan Hospital, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
²⁴ Center for Critical Care Medicine, Bach Mai Hospital, Hanoi, Vietnam.
²⁵ Department of Emergency and Critical Care Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.
²⁶ Department of Emergency and Critical Care Medicine, Hanoi Medical University, Hanoi, Vietnam.
²⁷ Critical Care Medicine Unit, The University of Hong Kong, Hong Kong SAR, China.
²⁸ Department of Adult Intensive Care, Queen Mary Hospital, Hong Kong SAR, China.
²⁹ Kulliyyah of Medicine, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
³⁰ Acute and Critical Care Institute, The Medical City, Pasig, Philippines.
³¹ Department of Anaesthesiology and Intensive Care Unit, Ege University School of Medicine Hospital, Izmir, Turkey.
³² Department of Emergency Medicine, Provincial Key Laboratory of Precise Diagnosis and Treatment of Abdominal Infection, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³³ Critical Care Medicine, Lilavati Hospital and Research Centre, Mumbai, India.
³⁴ Division of Respiratory and Critical Care Medicine, Department of Medicine, Alexandra Hospital, National University Health System, Singapore, Singapore.
³⁵ Division of Respiratory and Critical Care Medicine, National University Hospital, National University Health System, Singapore, Singapore.
³⁶ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
³⁷ College of Medicine, King Abdullah International Medical Research Center, Intensive Care Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
³⁸ Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong SAR, China. lowell.ling@cuhk.edu.hk.
³⁹ Department of Intensive Care, Prince of Wales Hospital, Hong Kong SAR, China. lowell.ling@cuhk.edu.hk.

PMID: 40859362
PMCID: PMC12382108
DOI: 10.1186/s40560-025-00816-9

Abstract

Background: Practice and delivery of critical care in Asia varies according to healthcare structure, income setting, and cultural factors. Identifying research priorities specific to ICU patients and healthcare workers in Asia is needed to guide advancement of critical care in the region.

Methods: This was an international cross-sectional survey study with adapted methods from nominal group techniques. All members of the Asian Critical Care Clinical Trials (ACCCT) Group were invited to submit research question suggestions. Submitted research questions were combined into summarized research questions, grouped into research themes, and individually ranked by number of mentions based on the original question submission (popularity). National and Regional Representatives rated the top 15% most popular summarized research questions by pre-defined importance and feasibility criteria.

Results: Between September 20, 2024 and December 10, 2024, 160 of 228 general members of the ACCCT Group (response rate 70.2%) participated in this survey study. The participants were from 112 hospitals across 24 countries and regions within Asia. Participants submitted 408 research questions, which were categorized into 15 themes and combined into 197 summarized research questions. The top three themes, as ranked by the number of mentions, were infection/sepsis, general ICU care, and structure/training/staffing/teamwork/safety. A threshold of 4 mentions was used to identify 26 summarized research questions that represented the top 15% most popular questions. Research questions related to sepsis and acute respiratory distress syndrome were ranked most important and feasible across the region.

Conclusion: Twenty-six of the most popular research questions in critical care were identified by Asian ICU workers and researchers to drive research agenda in Asia for the next decade.

Keywords: Agenda; Clinical study; Critical care; Feasibility; Importance; Interest; International; Investigation; Relevance.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study was approved by the Survey and Behavioural Research Ethics Committee of The Chinese University of Hong Kong (SBRE-23-0325). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

**Fig. 1**
Geographical distribution of participants. The geographical distribution of phase 2 survey participants

**Fig. 2**
Popularity of research themes. The proportion of mentions from all suggested research questions accumulated by all research themes. *AKI* acute kidney injury, *ECLS* extracorporeal life support

**Fig. 3**
Priority ranking of top 26 summarized research questions. Priority ranking of the top 26 summarized research questions by overall importance and feasibility score. Popularity of each summarized research question is calculated from the number of mentions for each question from 408 original submitted research questions in phase 2

See this image and copyright information in PMC

References

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Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU)

Collaborators

Affiliations

Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU)

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources