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. 2025 Aug 25;6(1):sgaf013.
doi: 10.1093/schizbullopen/sgaf013. eCollection 2025 Jan.

Sample Ascertainment and Recruitment Sources in the Accelerating Medicines Partnership Schizophrenia Program

Jean Addington  1 Amy Shalev  1 Lu Liu  1 Cari Jahraus  1 Monica Chu  1 Emily Farina  2 Paolo Fusar Poli  3   4 Patricia J Marcy  5 Angela R Nunez  2   6 Monica E Calkins  7 Luis Alameda  3   8   9 Celso Arango  10 Owen Borders  11 Sylvain Bouix  12 Nicholas J K Breitborde  13 Matthew R Broome  14   15 Kristin S Cadenhead  16 Ricardo E Carrion  5   17   18 Rolando I Castillo-Passi  19   20 Eric Yu Hai Chen  21 Jimmy Choi  22 Michael J Coleman  11 Philippe Conus  23 Cheryl M Corcoran  24 Covadonga M Diaz-Caneja  10 Lauren M Ellman  25 Pablo A Gaspar  19 Carla Gerber  26   27 Louise Birkedal Glenthøj  28   29 Leslie E Horton  30 Christy Lai Ming Hui  21 Joseph Kambeitz  31 Lana Kambeitz-Ilankovic  31   32 Tina Kapur  33 Sinead Kelly  11 Melissa J Kerr  34 Matcheri S Keshavan  35 Minah Kim  36   37 Sung-Wan Kim  38   39 Nikolaos Koutsouleris  3   40   41 Jun Soo Kwon  37   42 Kerstin Langbein  43 Kathryn E Lewandowski  44   45 Daniel Mamah  46 Daniel H Mathalon  47   48 Vijay A Mittal  49 Catalina Mourgues  2 Merete Nordentoft  28   50 Ofer Pasternak  11   33   51 Godfrey D Pearlson  2   52 Nora Penzel  11   40   51 Jesus Perez  53   54 Diana O Perkins  55 Albert R Powers 3rd  2   6 Jack Rogers  14   56 Fred W Sabb  26 Jason Schiffman  57 Johanna Seitz-Holland  11   51 Jai L Shah  58   59 Steven M Silverstein  60 Stefan Smesny  43 William S Stone  61 Gregory P Strauss  62 Judy L Thompson  63 Rachel Upthegrove  14   64 Swapna Verma  65   66 Jijun Wang  67 Daniel H Wolf  7 Alison R Yung  68   69 Tianhong Zhang  70 Lauren Addamo  34   71 Kate Buccilli  34   71 Sophie Todd  34   71 Dominic Dwyer  34   71 Carrie E Bearden  72 John M Kane  73   74 Patrick D McGorry  34   71 Rene S Kahn  24 Martha E Shenton  51   75 Scott W Woods  2 Accelerating Medicines Partnership® Schizophrenia Nelson Barnaby
Affiliations

Sample Ascertainment and Recruitment Sources in the Accelerating Medicines Partnership Schizophrenia Program

Jean Addington et al. Schizophr Bull Open. .

Abstract

Background: This paper presents the recruitment sources of clinical high-risk (CHR) and community controls (CC) from the Accelerating Medicines Partnership Schizophrenia (AMP SCZ) program, which aims to study various clinical variables and biomarkers in 2040 CHR and 652 CC participants.

Methods: A total of 1640 CHR and 514 CC had recruitment source data. The Positive Symptoms and Diagnostic Criteria for the Comprehensive Assessment of At-Risk Mental States Harmonized with the SIPS was utilized to assess CHR criteria and severity of attenuated psychotic symptoms (APSs), and the Global Functioning: Social Scale was used for social functioning. Participants were recruited through various methods, including referrals from healthcare providers, schools, and community agencies, and self-referrals via outreach efforts and advertising.

Results: Participants were recruited from 13 different sources, with self-referral being the most common for both CHR and CC. Other notable sources included child and youth services and psychiatric hospitals and departments. Regional differences in recruitment patterns were observed across continents. Differences in age, APS, and social functioning for CHR participants were examined in the top 5 recruitment sources. Overall, self-referred individuals were typically older, with less severe APS and higher levels of functioning, whereas those from adult community mental health services had poorer functioning and more severe APS. The remaining recruitment groups fell between these 2 extremes.

Conclusion: This paper highlights the diverse recruitment sources for the AMP SCZ program. Self-referral was a significant source, particularly in North America, reflecting changing help-seeking behaviors influenced by the internet and social media. The findings underscore the importance of understanding recruitment sources to optimize future CHR research.

Keywords: AMP SCZ; ascertainment; clinical high risk; community controls; psychosis; recruitment.

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Conflict of interest statement

Dr. C. Arango has been a consultant to and/or has received honorarium and or grants from Acadia, Angelini, Biogen, Boehringer Ingelheim, Gideon Richter, Janssen Cilag, Lundbeck, Medscape, Menarini, Minerva, Otsuka, Pfizer, Roche, Sage, Servier, Shire, Shering Plough, Sumitomo Dainippon Pharma, Sunovian, and Takeda. Dr. R. Upthegrove has received speaker fees for Otsuka and consulted to Viatris and Springer Healthcare. Dr. P. Fusar Poli has received research funds or personal fees from Angelini, Boehringer Ingelheim, Lundbeck, Menarini, Otsuka, Sunovian, and Proxymm Science. Dr. S. Woods has received speaking fees from the American Psychiatric Association and from Medscape Features. He has been granted US patent no. 8492418 B2 for a method of treating prodromal schizophrenia with glycine agonists. He owns stock in NW PharmaTech. Dr. C. Diaz-Caneja has received grant support from Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation and honoraria or travel support from Angelini, Janssen, and Viatris. Dr. Kambeitz has received speaking or consulting fees from Janssen, Boehringer Ingelheim, ROVI, and Lundbeck. Patricia J. Marcy is a consultant for Otsuka and TEVA. Dr. R. S. Kahn is a consultant for Alkermes, Boehringer Ingelheim. Dr. J. Kane Consultant to or receives honoraria and/or travel support and/or speakers bureau: Alkermes, Allergan, Boehringer Ingelheim, Cerevel, Dainippon Sumitomo, H. Lundbeck, HealthRhythms, HLS Therapeutics, Indivior, Intracellular Therapies, Janssen Pharmaceutical, Johnson & Johnson, Karuna Therapeutics/Bristol Meyer-Squibb, LB Pharmaceuticals, Mapi, Maplight, Merck, Minerva, Neurocrine, Newron, Novartis, NW PharmaTech, Otsuka, Roche, Saladax, Sunovion, and Teva. Advisory Boards: Alkermes, Boehringer Ingelheim, Cerevel, Click Therapeutics, Karuna/BMS, Lundbeck, Merck, Newron, Novartis, Otsuka, Sumitomo, Teva, and Terran. Grant Support: Lundbeck, Janssen, Otsuka, and Sunovion. Shareholder interests: Cerevel (public/stock), HealthRhythms (private/stock options), Karuna/BMS (public), LB Pharmaceuticals, Inc. (private/stock options), North Shore Therapeutics (private/stock), and Vanguard Research Group (private/40% owner). All other authors report no competing interests.

Figures

Figure 1
Figure 1
Percentages of CHR and CC Participants in Each of the Recruitment Sources.
Figure 2
Figure 2
Percentages of CHR Participants from ProNET and PRESCIENT in Each of the Recruitment Sources.

References

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