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. 2025 Aug 25;9(8):e70208.
doi: 10.1002/hem3.70208. eCollection 2025 Aug.

Preliminary evidence of CAR T-cell therapy activity in vitreoretinal lymphomas: An LOC network study

Cécile Pivert  1 , Adélaïde Toutée  2 , Christophe Parizot  3 , Denis Malaise  4 , Alexandre Matet  4 , Valérie Touitou  2 , Magali Le Garff-Tavernier  5 , Damien Roos-Weil  1 , Sarah Touhami  2 , Nabih Azar  6 , Ines Boussen  1 , Véronique Morel  1 , Madalina Uzunov  1 , Clotilde Bravetti  5 , Carole Metz  7 , Eve Todesco  8 , Delphine Sterlin  3 , Carole Soussain  9 , Kahina Ouis Tarhi  10 , Anne Besançon  11 , Khê Hoang-Xuan  12 , Sylvain Choquet  1 , Caroline Houillier  12 , Marine Baron  1
Affiliations

Preliminary evidence of CAR T-cell therapy activity in vitreoretinal lymphomas: An LOC network study

Cécile Pivert et al. Hemasphere. .
No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(A) Overall survival (OS) and progression‐free survival (PFS). (B) Ultrawide‐field fundus photography of the left eye of a 66‐year‐old woman with a PVRL. The peripheral residual vitritis (white arrows) present before (a) and resolved 1 month after chimeric antigen receptor (CAR) T‐cells (b). (C) Example dot plots of CAR T‐cell positivity among CD3+ lymphocytes (left) and CD4 and CD8 distribution among CAR T‐cells (right) in peripheral blood (upper panel) and aqueous humor (AH) (lower panel) at Day 11. For this patient, the AH was collected at Day 11 and Months 1, 4, and 10 and was tested positive for CAR T‐cells using flow cytometry after incubating with CD19 CAR detection reagent. PVRL, primary vitreoretinal lymphoma.
See this image and copyright information in PMC

References

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