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. 2025 Oct 9;14(10):e0062525.
doi: 10.1128/mra.00625-25. Epub 2025 Aug 27.

BK polyomavirus genotype IV isolates from virus-specific T-cell therapy recipients

Tiana A Walder  1 , Heidi L Meeds  1 , Michael S Grimley  2 , Steven B Kleiboeker  3 , Assem Ziady  2   4 , Anthony Sabulski  2   4 , Sonata Jodele  2   4 , Alix E Seif  5   6 , Stella M Davies  2   4 , Benjamin L Laskin  5   7 , Jason T Blackard  1 , Jeremy D Rubinstein  8
Affiliations

BK polyomavirus genotype IV isolates from virus-specific T-cell therapy recipients

Tiana A Walder et al. Microbiol Resour Announc. .

Abstract

BK polyomavirus (BKPyV) can cause disease in transplant recipients. Virus-specific T-cell (VST) therapy is effective in decreasing virus levels in many individuals. BKPyV genetic variation can impact replication kinetics and immune responses. Here, we present the near full-length BKPyV genome sequences from two VST recipients in which genotype IV was isolated.

Keywords: BK polyomavirus; genotype; transplantation; viral diversity; virus-specific T-cell therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig 1
Fig 1
A multiple sequence alignment was carried out utilizing ClustalX 2.1 with pairwise alignment parameters. A phylogenetic tree was generated using the neighbor-joining algorithm. Five reference sequences were selected to represent each major BKPyV genotype (Ia, Ib1, Ib2, Ic, II, III, and IV), such that each reference represented a different country of origin. References are labeled with their GenBank accession number, country of origin, and BKPyV genotype. The subject sequences are highlighted in red and are labeled with their GenBank accession number.
See this image and copyright information in PMC

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