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. 1985 Jan;21(1):26-31.
doi: 10.1007/BF02620910.

The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts

R A Levy, R E Ostlund Jr, J Brajtburg

The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts

R A Levy et al. In Vitro Cell Dev Biol. 1985 Jan.

Abstract

Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.

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