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. 2025 Nov;90(2):852-862.
doi: 10.1007/s12020-025-04398-2. Epub 2025 Aug 27.

A knee bone age-based predictive nomogram for the poor response to growth hormone therapy in children with idiopathic short stature during mid-to-late puberty

Yuxin Sun #  1   2 , Zhibo Zhou #  1 , Jiaqi Qiang  1 , Fengdan Wang  3 , Shi Chen  4 , Hui Pan  5
Affiliations

A knee bone age-based predictive nomogram for the poor response to growth hormone therapy in children with idiopathic short stature during mid-to-late puberty

Yuxin Sun et al. Endocrine. 2025 Nov.
No abstract available

Keywords: Bone age; Growth hormone therapy; Idiopathic short stature; Magnetic resonance imaging; Puberty.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests. Statements and Declarations: This study was funded by the National Key Research and Development Program, with data available upon reasonable request, approved by the Ethics Committee of Peking Union Medical College Hospital, and the authors declare no conflicts of interest, confirming the work is original and has not been submitted or published elsewhere.

References

    1. S. Pedicelli, E. Peschiaroli, E. Violi, S. Cianfarani, Controversies in the definition and treatment of idiopathic short stature (ISS). J. Clin. Res. Pediatr. Endocrinol. 1(3), 105–115 (2009). https://doi.org/10.4008/jcrpe.v1i3.53 - DOI - PubMed - PMC
    1. W. Zegarra, S. Ranadive, D. Toulan, E.K. Neely, Anastrozole vs letrozole to augment height in pubertal males with idiopathic short stature: A 3-Year randomized trial. J. Endocr. Soc. 8(10), bvae141 (2024). https://doi.org/10.1210/jendso/bvae141 - DOI - PubMed - PMC
    1. A. Deodati, S. Cianfarani, Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ. 342, c7157 (2011). https://doi.org/10.1136/bmj.c7157 - DOI - PubMed
    1. L. Torres-Santiago, N. Mauras, Approach to the peripubertal patient with short stature. J. Clin. Endocrinol. Metab. 109(7), e1522–e1533 (2024). https://doi.org/10.1210/clinem/dgae011 - DOI - PubMed
    1. M. Yackobovitch-Gavan, A. Tenenbaum, M. Phillip, L. Lazar, T. Oron, Aromatase-inhibitors treatment alone or with GH increases final height in Short-Statured pubertal Boys - Real-World data. J Clin. Endocrinol. Metab Published Online April. 7, dgaf224 (2025). https://doi.org/10.1210/clinem/dgaf224 - DOI

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