Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Aug 8;26(8):763-777.
doi: 10.1631/jzus.B2500127.

Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health

[Article in English, Chinese]
Yiyan Yang  1 , Jue Zhou  2
Affiliations
Review

Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health

[Article in English, Chinese]
Yiyan Yang et al. J Zhejiang Univ Sci B. .

Abstract
in English, Chinese, Chinese

Citrus, which has been consumed internationally for a long time, is widely used as a health food. Citrus and its active components exert significant effects on oxidative stress and lipid metabolism, which are closely associated with female reproductive health. Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1), and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptor α (PPARα). This review focuses on the effects of Citrus on oxidative stress and lipid metabolism, aiming to provide new insights for promoting female reproductive health; however, further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus's bioactive components in clinical settings.

柑橘在国际上拥有悠久的食用历史，广泛被用作健康食品。柑橘及其活性成分对氧化应激和脂质代谢具有显著的调节作用，这些因素与女性生殖健康密切相关。研究表明，柑橘来源的化合物可能通过激活Nrf2和SIRT1等信号通路缓解氧化应激，并通过激活包括PPARα在内的信号通路改善脂质代谢。本文综述了柑橘对氧化应激和脂质代谢的影响，旨在为促进女性生殖健康提供新思路。然而，仍需进一步的研究明确其作用机制，且柑橘活性成分的临床治疗潜力仍有待验证。.

柑橘在国际上拥有悠久的食用历史，广泛被用作健康食品。柑橘及其活性成分对氧化应激和脂质代谢具有显著的调节作用，这些因素与女性生殖健康密切相关。研究表明，柑橘来源的化合物可能通过激活Nrf2和SIRT1等信号通路缓解氧化应激，并通过激活包括PPARα在内的信号通路改善脂质代谢。本文综述了柑橘对氧化应激和脂质代谢的影响，旨在为促进女性生殖健康提供新思路。然而，仍需进一步的研究明确其作用机制，且柑橘活性成分的临床治疗潜力仍有待验证。

Keywords: Citrus; Female reproductive health; Food; Lipid metabolism; Oxidative stress.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Potential role of Citrus in improving the female reproductive system based on its effects on oxidative stress and lipid metabolism. PPARα: peroxisome proliferator-activated receptor α; MDA: malondialdehyde; mtDNA: mitochondrial DNA; 4-HNE: 4-hydroxynonenal; SOD: superoxide dismutase; GSH: glutathione; ROS: reactive oxygen species; TG: triglyceride; LDL: low-density lipoprotein; HDL: high-density lipoprotein; VLDL: very low-density lipoprotein. Created with BioRender.com.
See this image and copyright information in PMC

References

    1. Abo-Zaid OAR, Moawed FSM, Ismail ES, et al. , 2023. β-Sitosterol attenuates high-fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway. BMC Pharmacol Toxicol, 24: 31. 10.1186/s40360-023-00671-0 - DOI - PMC - PubMed
    1. Agarwal A, Gupta S, Sharma RK, 2005. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol, 3: 28. 10.1186/1477-7827-3-28 - DOI - PMC - PubMed
    1. Alam F, Mohammadin K, Shafique Z, et al. , 2022. Citrus flavonoids as potential therapeutic agents: a review. Phytother Res, 36(4): 1417-1441. 10.1002/ptr.7261 - DOI - PubMed
    1. Alam MA, Subhan N, Rahman MM, et al. , 2014. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr, 5(4): 404-417. 10.3945/an.113.005603 - DOI - PMC - PubMed
    1. Alimohammadi M, Mohammad RN, Rahimi A, et al. , 2022. The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical evidence. Inflamm Res, 71(10-11): 1127-1142. 10.1007/s00011-022-01599-7 - DOI - PubMed

LinkOut - more resources