Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB₁

Tian Hua^{1

2

3}, Kiran Vemuri^#⁴, Spyros P Nikas^#⁴, Robert B Laprairie⁵, Yiran Wu¹, Lu Qu^{1

2

3}, Mengchen Pu¹, Anisha Korde⁴, Shan Jiang⁴, Jo-Hao Ho⁵, Gye Won Han⁶, Kang Ding^{1

3

7}, Xuanxuan Li⁸, Haiguang Liu⁸, Michael A Hanson⁹, Suwen Zhao^{10

11}, Laura M Bohn¹², Alexandros Makriyannis¹³, Raymond C Stevens^{1

6

7}, Zhi-Jie Liu^{14

15

16}

Affiliations

¹ iHuman Institute, ShanghaiTech University, Shanghai, China.
² National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
³ University of Chinese Academy of Sciences, Beijing, China.
⁴ Center for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
⁵ Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA.
⁶ Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, California, USA.
⁷ School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
⁸ Complex Systems Division, Beijing Computational Science Research Center, Beijing, China.
⁹ GPCR Consortium, San Marcos, California, USA.
¹⁰ iHuman Institute, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.
¹¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.
¹² Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA. lbohn@scripps.edu.
¹³ Center for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA. a.makriyannis@northeastern.edu.
¹⁴ iHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.
¹⁵ National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. liuzhj@shanghaitech.edu.cn.
¹⁶ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.

^# Contributed equally.

PMID: 40866714
DOI: 10.1038/s41586-025-09538-2

Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB₁

Tian Hua et al. Nature. 2025 Sep.

. 2025 Sep;645(8080):544.

doi: 10.1038/s41586-025-09538-2.

Authors

Affiliations

¹ iHuman Institute, ShanghaiTech University, Shanghai, China.
² National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
³ University of Chinese Academy of Sciences, Beijing, China.
⁴ Center for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
⁵ Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA.
⁶ Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, California, USA.
⁷ School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
⁸ Complex Systems Division, Beijing Computational Science Research Center, Beijing, China.
⁹ GPCR Consortium, San Marcos, California, USA.
¹⁰ iHuman Institute, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.
¹¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. zhaosw@shanghaitech.edu.cn.
¹² Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute, Jupiter, Florida, USA. lbohn@scripps.edu.
¹³ Center for Drug Discovery, Department of Pharmaceutical Sciences; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA. a.makriyannis@northeastern.edu.
¹⁴ iHuman Institute, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.
¹⁵ National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. liuzhj@shanghaitech.edu.cn.
¹⁶ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. liuzhj@shanghaitech.edu.cn.

^# Contributed equally.

PMID: 40866714
DOI: 10.1038/s41586-025-09538-2

No abstract available

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Retraction of

Crystal structures of agonist-bound human cannabinoid receptor CB₁.
Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Hua T, et al. Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5. Nature. 2017. Retraction in: Nature. 2025 Sep;645(8080):544. doi: 10.1038/s41586-025-09538-2. PMID: 28678776 Free PMC article. Retracted.

References

1. Hua, T. et al. Crystal structures of agonist-bound human cannabinoid receptor CB₁. Nature https://doi.org/10.1038/s41586-025-09454-5 (2025). - DOI - PubMed - PMC

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Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB₁

Affiliations

Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB₁

Authors

Affiliations

Retraction of

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