Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 8;15(8):1262.
doi: 10.3390/life15081262.

Correlating Various Clinical Outcomes and Associated Dispositions in Patients with Severe Traumatic Brain Injury (TBI)

Affiliations

Correlating Various Clinical Outcomes and Associated Dispositions in Patients with Severe Traumatic Brain Injury (TBI)

Bharti Sharma et al. Life (Basel). .

Abstract

Background: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Patient disposition following TBI has been shown to interact with factors such as age, sex, and injury severity to impact clinical outcomes. Discharge home is associated with better functional outcomes and lower mortality, while discharge to rehabilitation or long-term care facilities is linked to greater injury severity, older age, and higher comorbidity burden. The aim of this study was to further correlate clinical outcomes with discharge dispositions in patients with severe TBI. Methods: This is a retrospective study (2020-2023) of dispositions in patients with severe TBI with AIS (head) ≥ 3. We investigated the relationship between patient disposition and a range of clinical variables, using both parametric (ANOVA) and non-parametric (Kruskal-Wallis, Wilcoxon, Van der Waerden, Savage, Kolmogorov-Smirnov, and Cramer-von Mises) statistical tests. Variables significant in univariate analysis were entered into a multinomial logistic regression model, with discharge home as the reference group. Results: In a cohort of 824 patients, 25.1% were female (n = 207) and 74.9% were male (n = 617). The mean age was 64.1 years for females and 48.9 years for males. Those admitted for severe TBI were included in our analysis. Most patients were discharged home (52.8%), followed by death (12.4%), inpatient rehab (5.1%), and home with services (5.6%). Significant associations were found between disposition and sex, with both males and females most likely to be discharged home (p = 0.0174), as well as between disposition and injury type (p = 0.0186). Disposition was significantly associated with most major clinical variables: hospital length of stay (HLOS), vent days, Glasgow Coma Scale (GCS), and Injury Severity Score (ISS), with p-values < 0.0001 for ANOVA and non-parametric tests. Longer HLOS and ICULOS were associated with discharge to skilled nursing facilities (SNF) most frequently. Days on mechanical ventilation correlated most strongly with discharge to SNF. Lower GCS scores and higher AIS and ISS scores were linked to death or brain death. Prolonged EDLOS was predominantly associated with psychiatric admissions. Higher levels of ETOH were associated with discharge to police custody, followed by homelessness. Conclusions: Our study supports existing evidence that discharge disposition following severe TBI is influenced by several factors, such as injury severity, age, sex, and clinical variables, such as length of stay and ventilator days.

Keywords: discharge disposition; injury severity; length of stay; mechanism of injury; traumatic brain injury.

PubMed Disclaimer

Conflict of interest statement

The authors have no competing interests to declare.

Figures

Figure 1
Figure 1
GCS vs. Disposition. This boxplot illustrates the distribution of average Glasgow Coma Scale (GCS) scores by disposition category. Lower GCS scores were predominantly observed in patients who died or were declared brain dead, whereas higher scores were associated with dispositions such as homelessness or discharge against medical advice (AMA). Patients discharged to Skilled Nursing Facilities (SNF), TBI Rehabilitation, or Inpatient Rehabilitation exhibited a broad range of GCS scores. Abbreviations: AMA = Discharged Against Medical Advice; SAR = Subacute Rehabilitation; SNF = Skilled Nursing Facility.
Figure 2
Figure 2
ISS vs. Disposition. This boxplot illustrates the distribution of average Injury Severity Score (ISS) by disposition category. Higher ISS scores were observed in patients who died, were declared brain dead, or were discharged to a skilled nursing facility (SNF). Lower scores were associated with discharge to psychiatric care, homeless, or police custody dispositions. Abbreviations: AMA = Discharged Against Medical Advice; SAR = Subacute Rehabilitation; SNF = Skilled Nursing Facility.

Similar articles

References

    1. Traumatic Brain Injury (TBI). National Institute for Neurological Disorders and Stroke. [(accessed on 28 April 2025)];2024 Available online: https://www.ninds.nih.gov/health-information/disorders/traumatic-brain-i....
    1. Carlson K., Kehle S., Meis L., Greer N., MacDonald R., Rutks I., Wilt T.J. The Assessment and Treatment of Individuals with a History of Traumatic Brain Injury and Post-Traumatic Stress Disorder: A Systematic Review of the Evidence [Internet] Department of Veterans Affairs; Washington, DC, USA: 2009. [(accessed on 28 April 2025)]. Comparison of Mild TBI with Moderate and Severe TBI* Available online: https://www.ncbi.nlm.nih.gov/books/NBK49142/table/introduction.tu1/ - PubMed
    1. GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2021;20:e7. doi: 10.1016/S1474-4422(21)00383-5. - DOI - PMC - PubMed
    1. American College of Emergency Physicians Clinical Policies Subcommittee (Writing Committee) on Mild Traumatic Brain Injury. Valente J.H., Anderson J.D., Paolo W.F., Sarmiento K., Tomaszewski C.A., Haukoos J.S., Diercks D.B., Members of the American College of Emergency Physicians Clinical Policies Committee (Oversight Committee) Diercks D.B., et al. Clinical Policy: Critical Issues in the Management of Adult Patients Presenting to the Emergency Department with Mild Traumatic Brain Injury: Approved by ACEP Board of Directors, February 1, 2023 Clinical Policy Endorsed by the Emergency Nurses Association (April 5, 2023) Ann. Emerg. Med. 2023;81:e63–e105. doi: 10.1016/j.annemergmed.2023.01.014. - DOI - PMC - PubMed
    1. Miller G.F., DePadilla L., Xu L. Costs of Nonfatal Traumatic Brain Injury in the United States, 2016. Med. Care. 2021;59:451–455. doi: 10.1097/MLR.0000000000001511. - DOI - PMC - PubMed

LinkOut - more resources