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. 1985 Dec;48(12):1265-8.
doi: 10.1136/jnnp.48.12.1265.

Laser injury of peripheral nerve: a model for focal endoneurial damage

R R Myers, H E James, H C Powell

Laser injury of peripheral nerve: a model for focal endoneurial damage

R R Myers et al. J Neurol Neurosurg Psychiatry. 1985 Dec.

Abstract

A model of endoneurial oedema is presented which produces localised nerve fibre injury including Wallerian degeneration, endoneurial oedema and increased endoneurial fluid pressure. A carbon dioxide laser was used to irradiate rat sciatic nerve and quantitative results were collected 2 days and 6 days after irradiation. The increase in endoneurial fluid pressure is compared with other models of Wallerian degeneration in which the entire fascicle was involved to aid in a comparative study of the role of oedema in neuropathy.

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