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Review
. 2025 Aug 12;61(8):1446.
doi: 10.3390/medicina61081446.

Supramarginal Resection of Metastatic Brain Tumors: A Meta-Analysis Study

Florin Adrian Tofan  1 , Ahmed T Massoud  2 , Cosmin Ioan Faur  3 , Stefan Ioan Florian  1
Affiliations
Review

Supramarginal Resection of Metastatic Brain Tumors: A Meta-Analysis Study

Florin Adrian Tofan et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Over 30% of people who suffer from cancers are at risk of developing brain metastases. The typical recommended surgical therapy for metastases within the brain is gross total resection (GTR). Nevertheless, GTR solely may not always be adequate for disease management since remaining tumors can show local advancements and invasion. The focus of this research is to summarize the current data and to compare the outcomes of GTR and supramarginal resection. Materials and Methods: A search on the PubMed, Scopus, Cochrane Central Library, and Web of Science (WOS) databases was performed using specific keywords for single or multiple brain metastasis of any origin in patients who underwent either supramarginal resection or gross total resection. Results: The average age of the patients involved in the study spanned between 51 ± 6 years and 60.5 ± 10.1 years. Males represented 48.7% of the total population. The incidence of 1-year survival among the GTR group was 37.1%, whereas the supramarginal resection group showed an incidence of 91.3%, under the random effect model (0.551, 95% CI [0.18, 0.921]). The incidence of 2-year survival among the GTR group was 21.26%, whereas the supramarginal resection group showed an incidence of 72.46%, under the random effect model (0.380, 95% CI [0.113, 0.648]). The incidence of local recurrence among the GTR group was 57.69%, whereas the supramarginal resection group showed an incidence of 18.4%, under the random effect model (0.266, 95% CI [0.106, 0.426]). Conclusions: Supramarginal resection is a promising approach for the management of brain metastases.

Keywords: brain metastases; gross total resection; supramarginal resection.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Selection process of the eligible studies.
Figure 2
Figure 2
Forest plot of 1-year overall survival outcome [21,22,25].
Figure 3
Figure 3
Forest plot of 2-year overall survival outcome [21,22,25].
Figure 4
Figure 4
Forest plot of the incidence of local recurrence of brain metastases [21,23,24].
See this image and copyright information in PMC

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